Detailed information of TA system TA031437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 2337944..2338497
• Replicon: chromosome
• Accession: NZ_AP017928
• Organism: Methylocaldum marinum strain S8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: sS8_RS10090
• Protein ID: WP_119629536.1
• Coordinates: 2337944..2338234 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: sS8_RS10095
• Protein ID: WP_119629537.1
• Coordinates: 2338231..2338497 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
sS8_RS10070	2333716..2334711	+	996	WP_119629532.1	type I-C CRISPR-associated protein Cas7/Csd2	-
sS8_RS10075	2334708..2335349	+	642	WP_119629533.1	CRISPR-associated protein Cas4	-
sS8_RS10080	2335346..2336380	+	1035	WP_119629534.1	type I-C CRISPR-associated endonuclease Cas1	-
sS8_RS10085	2336392..2336682	+	291	WP_119629535.1	CRISPR-associated endonuclease Cas2	-
sS8_RS10090	2337944..2338234	-	291	WP_119629536.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
sS8_RS10095	2338231..2338497	-	267	WP_119629537.1	CopG family ribbon-helix-helix protein	Antitoxin
sS8_RS27620	2338677..2338931	+	255	WP_145986482.1	hypothetical protein	-
sS8_RS10100	2338998..2340170	-	1173	WP_119629538.1	NnrS family protein	-
sS8_RS10105	2340493..2340888	-	396	WP_119629539.1	DUF488 domain-containing protein	-
sS8_RS10110	2341066..2341395	+	330	WP_179952406.1	DUF1820 family protein	-
sS8_RS10115	2341423..2341818	-	396	WP_119629541.1	ClpXP protease specificity-enhancing factor	-
sS8_RS10120	2341818..2342465	-	648	WP_119632703.1	glutathione S-transferase N-terminal domain-containing protein	-
sS8_RS10125	2342616..2343338	-	723	WP_119629542.1	cytochrome c1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	pilU / pilT / gmd / clpV1 / hcp1 / hsiC1/vipB / hsiB1/vipA / gmd / htpB / cheW / cheY / flhA / tufA / ureG / ureA / sodB / tufA / htpB / flmH / acpXL / CBU_1566	535..6088915	6088380

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11332.97 Da
• Isoelectric Point: 9.4009

>T31437 WP_119629536.1 NZ_AP017928:c2338234-2337944 [Methylocaldum marinum]
VKIVWARPARQDLRDIYLYIAQDNPYAARKLQSEIRQRVALLQDNPGFGRTDRVTGTRELVMGDSPYILPYRVRQDCIEI
LAVYHGARKWPEEFRE

Nucleotide

• Length: 291 bp

>T31437 NZ_AP017928:c2338234-2337944 [Methylocaldum marinum]
GTGAAAATCGTCTGGGCCAGACCCGCCCGCCAAGACTTGCGGGACATTTACCTTTATATCGCCCAAGATAATCCCTACGC
AGCGCGTAAGCTCCAGAGCGAAATCCGGCAACGCGTTGCGCTTCTTCAAGACAATCCCGGATTCGGCCGCACCGACCGAG
TCACCGGGACGCGGGAACTGGTAATGGGCGATTCCCCCTACATTCTGCCTTACCGTGTACGTCAGGACTGCATCGAAATC
TTGGCTGTTTACCACGGTGCTCGGAAATGGCCGGAGGAATTCCGAGAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10045.31 Da
• Isoelectric Point: 4.5355

>AT31437 WP_119629537.1 NZ_AP017928:c2338497-2338231 [Methylocaldum marinum]
MTTEAFTVRTDGETVKRLDQLAAQLDRSRNYLVNQAIQEYLKLHAWQIQKIEAGIAAADRGDVIPHEDVMGEMDALIEEK
IRAFEDRS

Nucleotide

• Length: 267 bp

>AT31437 NZ_AP017928:c2338497-2338231 [Methylocaldum marinum]
ATGACGACCGAAGCCTTTACCGTCCGCACTGACGGCGAGACCGTTAAACGCCTTGACCAGCTCGCAGCACAGCTCGACCG
CTCGCGCAATTACCTGGTGAACCAGGCGATCCAGGAATATCTGAAACTGCATGCTTGGCAGATCCAAAAAATTGAGGCCG
GCATTGCCGCCGCCGATCGCGGCGATGTGATTCCGCATGAGGACGTGATGGGCGAGATGGACGCCTTGATTGAAGAAAAA
ATCAGAGCGTTCGAAGACCGTTCGTGA