Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2076284..2076798 Replicon chromosome
Accession NZ_AP017922
Organism Staphylococcus aureus strain JP02758

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JP49775_RS10380 Protein ID WP_000581792.1
Coordinates 2076284..2076493 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JP49775_RS10385 Protein ID WP_000138932.1
Coordinates 2076505..2076798 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JP49775_RS10360 2071792..2073150 - 1359 WP_029550321.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JP49775_RS10365 2073165..2074235 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
JP49775_RS10370 2074553..2075755 + 1203 WP_029550322.1 rod shape-determining protein RodA -
JP49775_RS10375 2076019..2076156 - 138 WP_000828354.1 hypothetical protein -
JP49775_RS10380 2076284..2076493 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
JP49775_RS10385 2076505..2076798 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JP49775_RS10390 2076964..2078448 + 1485 WP_000571550.1 cardiolipin synthase -
JP49775_RS10395 2078476..2079123 + 648 WP_001187614.1 HD domain-containing protein -
JP49775_RS10405 2079876..2080748 - 873 WP_000725800.1 membrane protein insertase YidC -
JP49775_RS10410 2080834..2081475 - 642 WP_000483161.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T31430 WP_000581792.1 NZ_AP017922:c2076493-2076284 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T31430 NZ_AP017922:c2076493-2076284 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT31430 WP_000138932.1 NZ_AP017922:c2076798-2076505 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT31430 NZ_AP017922:c2076798-2076505 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References