Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 825254..825730 Replicon chromosome
Accession NZ_AP017922
Organism Staphylococcus aureus strain JP02758

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JP49775_RS03925 Protein ID WP_000052076.1
Coordinates 825254..825442 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JP49775_RS03930 Protein ID WP_001059690.1
Coordinates 825470..825730 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JP49775_RS03895 821283..821765 + 483 WP_000824490.1 hypothetical protein -
JP49775_RS03900 822106..822792 + 687 WP_001574556.1 thermonuclease family protein -
JP49775_RS03905 823149..823349 + 201 WP_001059082.1 cold-shock protein -
JP49775_RS03910 823846..824064 - 219 WP_000005881.1 hypothetical protein -
JP49775_RS03915 824125..824409 - 285 WP_001004403.1 hypothetical protein -
JP49775_RS03920 824497..825066 - 570 WP_001106655.1 hypothetical protein -
JP49775_RS03925 825254..825442 - 189 WP_000052076.1 hypothetical protein Toxin
JP49775_RS03930 825470..825730 - 261 WP_001059690.1 hypothetical protein Antitoxin
JP49775_RS03935 826072..826275 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JP49775_RS03940 826272..826508 - 237 WP_000368687.1 hypothetical protein -
JP49775_RS03945 826733..827314 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
JP49775_RS03950 827387..828004 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
JP49775_RS03955 828153..828647 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
JP49775_RS03960 829046..829468 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
JP49775_RS03965 829616..830332 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T31422 WP_000052076.1 NZ_AP017922:c825442-825254 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T31422 NZ_AP017922:c825442-825254 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT31422 WP_001059690.1 NZ_AP017922:c825730-825470 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT31422 NZ_AP017922:c825730-825470 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References