Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3738511..3739040 Replicon chromosome
Accession NZ_AP017901
Organism Mycobacterium tuberculosis strain NCGM946K2

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CPZ08_RS18250 Protein ID WP_003417760.1
Coordinates 3738783..3739040 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CPZ08_RS18245 Protein ID WP_003417757.1
Coordinates 3738511..3738786 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ08_RS18235 3737252..3737545 - 294 WP_003417749.1 DUF3017 domain-containing protein -
CPZ08_RS18240 3737542..3738387 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CPZ08_RS18245 3738511..3738786 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CPZ08_RS18250 3738783..3739040 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CPZ08_RS18255 3739082..3740272 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CPZ08_RS18260 3740389..3740757 + 369 WP_003417765.1 FHA domain-containing protein -
CPZ08_RS18265 3740754..3741305 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CPZ08_RS18270 3741312..3741893 - 582 WP_003417769.1 ATP/GTP-binding protein -
CPZ08_RS18275 3741874..3742242 - 369 WP_003417772.1 DUF742 domain-containing protein -
CPZ08_RS18280 3742220..3742576 - 357 WP_031746267.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T31418 WP_003417760.1 NZ_AP017901:3738783-3739040 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T31418 NZ_AP017901:3738783-3739040 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT31418 WP_003417757.1 NZ_AP017901:3738511-3738786 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT31418 NZ_AP017901:3738511-3738786 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References