Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2220706..2221604 Replicon chromosome
Accession NZ_AP017901
Organism Mycobacterium tuberculosis strain NCGM946K2

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag CPZ08_RS10735 Protein ID WP_003410001.1
Coordinates 2220706..2221266 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag CPZ08_RS10740 Protein ID WP_003410003.1
Coordinates 2221263..2221604 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ08_RS10700 2215875..2216528 - 654 WP_003409976.1 cutinase Cfp21 -
CPZ08_RS10705 2216643..2216873 + 231 WP_003409980.1 DUF167 domain-containing protein -
CPZ08_RS10710 2216958..2217869 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
CPZ08_RS10715 2217978..2218577 + 600 WP_003409989.1 L-lysine exporter -
CPZ08_RS10720 2218993..2219421 + 429 WP_003906713.1 cellulose-binding protein -
CPZ08_RS10725 2219647..2220186 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
CPZ08_RS10735 2220706..2221266 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
CPZ08_RS10740 2221263..2221604 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
CPZ08_RS10745 2221690..2221947 + 258 WP_003410006.1 hypothetical protein -
CPZ08_RS10750 2221848..2222183 - 336 WP_003410009.1 dehydrogenase -
CPZ08_RS10755 2222272..2222616 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
CPZ08_RS10760 2222610..2222858 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
CPZ08_RS10765 2222958..2224907 - 1950 WP_023643701.1 cadmium-translocating P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T31395 WP_003410001.1 NZ_AP017901:c2221266-2220706 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T31395 NZ_AP017901:c2221266-2220706 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT31395 WP_003410003.1 NZ_AP017901:c2221604-2221263 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT31395 NZ_AP017901:c2221604-2221263 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References