Detailed information of TA system TA031358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2940804..2941344
• Replicon: chromosome
• Accession: NZ_AP017898
• Organism: Sphingopyxis sp. FD7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SPYCA_RS14155
• Protein ID: WP_172595090.1
• Coordinates: 2941057..2941344 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: SPYCA_RS14150
• Protein ID: WP_120221386.1
• Coordinates: 2940804..2941055 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPYCA_RS14125	2936368..2937798	+	1431	WP_120221378.1	3-isopropylmalate dehydratase large subunit	-
SPYCA_RS14130	2937822..2938670	+	849	WP_120221380.1	N-acyl homoserine lactonase family protein	-
SPYCA_RS14135	2938672..2939271	+	600	WP_120221382.1	3-isopropylmalate dehydratase small subunit	-
SPYCA_RS14140	2939364..2940359	+	996	WP_120222369.1	NADPH:quinone oxidoreductase family protein	-
SPYCA_RS14145	2940467..2940760	+	294	WP_120221384.1	hypothetical protein	-
SPYCA_RS14150	2940804..2941055	+	252	WP_120221386.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
SPYCA_RS14155	2941057..2941344	+	288	WP_172595090.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPYCA_RS14160	2941409..2943211	-	1803	WP_120221390.1	succinate dehydrogenase flavoprotein subunit	-
SPYCA_RS14165	2943213..2943617	-	405	WP_120221392.1	succinate dehydrogenase, hydrophobic membrane anchor protein	-
SPYCA_RS14170	2943610..2944053	-	444	WP_120221394.1	succinate dehydrogenase, cytochrome b556 subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-88)

Antitoxin

• Antitoxin ParD (4-75)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11012.35 Da
• Isoelectric Point: 6.2214

>T31358 WP_172595090.1 NZ_AP017898:2941057-2941344 [Sphingopyxis sp. FD7]
VAVRPEAEADIEDVADYTIEQWGAEQARHYVSDLRKAIEGLATNGLRHREEADVFPGLRRARSGHHLIFYLIDDERVDVL
RLLHERRDAMRHLKG

Nucleotide

• Length: 288 bp

>T31358 NZ_AP017898:2941057-2941344 [Sphingopyxis sp. FD7]
GTGGCTGTCCGCCCCGAAGCGGAAGCCGACATTGAAGACGTCGCTGATTACACCATCGAACAATGGGGCGCGGAGCAAGC
GCGCCATTATGTCAGCGATCTCCGCAAGGCGATCGAAGGACTTGCGACAAACGGATTACGCCACCGGGAAGAAGCGGATG
TTTTCCCGGGCTTAAGACGAGCCCGTAGCGGGCATCATCTGATCTTCTATCTGATCGACGACGAACGGGTCGATGTGCTC
CGCTTGTTGCACGAACGGCGGGATGCGATGCGGCACCTTAAGGGTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9502.73 Da
• Isoelectric Point: 5.2187

>AT31358 WP_120221386.1 NZ_AP017898:2940804-2941055 [Sphingopyxis sp. FD7]
MAVKNTSVALGEPFIEFARRKVESGEFATTSEVVREAMRRYIAYDDRVEALRREIKKGIDSGPARPFDWDAFMERKFGPE
SDA

Nucleotide

• Length: 252 bp

>AT31358 NZ_AP017898:2940804-2941055 [Sphingopyxis sp. FD7]
ATGGCTGTCAAGAACACTTCGGTCGCCCTGGGCGAACCCTTCATCGAATTTGCGCGCCGCAAGGTCGAATCGGGCGAGTT
CGCGACGACCAGCGAAGTCGTGCGCGAAGCGATGCGACGCTATATTGCCTATGATGATCGCGTCGAAGCGCTGCGCCGCG
AGATAAAGAAGGGCATCGACAGCGGCCCGGCGCGTCCATTTGACTGGGACGCCTTCATGGAACGGAAGTTCGGTCCCGAA
AGCGATGCGTAG