Detailed information of TA system TA031357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2627843..2628329
• Replicon: chromosome
• Accession: NZ_AP017898
• Organism: Sphingopyxis sp. FD7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPYCA_RS12505
• Protein ID: WP_120220876.1
• Coordinates: 2627843..2628127 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: SPYCA_RS12510
• Protein ID: WP_120220878.1
• Coordinates: 2628111..2628329 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPYCA_RS12485	2623278..2624168	+	891	WP_120220868.1	LysR family transcriptional regulator	-
SPYCA_RS12490	2624320..2625330	-	1011	WP_120220870.1	MipA/OmpV family protein	-
SPYCA_RS12495	2625513..2625743	+	231	WP_120220872.1	hypothetical protein	-
SPYCA_RS12500	2625790..2627718	+	1929	WP_120220874.1	1-deoxy-D-xylulose-5-phosphate synthase	-
SPYCA_RS12505	2627843..2628127	-	285	WP_120220876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPYCA_RS12510	2628111..2628329	-	219	WP_120220878.1	ribbon-helix-helix protein, CopG family	Antitoxin
SPYCA_RS12515	2628645..2629079	-	435	WP_197715345.1	PaaI family thioesterase	-
SPYCA_RS12520	2629160..2629501	+	342	WP_120220880.1	helix-turn-helix transcriptional regulator	-
SPYCA_RS12525	2629744..2630286	-	543	WP_172595063.1	DUF3035 domain-containing protein	-
SPYCA_RS12530	2630189..2630710	-	522	WP_120220884.1	signal peptidase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Protein of unknown function DUF6290 (3-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10974.68 Da
• Isoelectric Point: 10.6597

>T31357 WP_120220876.1 NZ_AP017898:c2628127-2627843 [Sphingopyxis sp. FD7]
MGWTLEVSDQARKQLRKIDIKQADRITRTMIDVAQLDDPRQRGHALVGDYAGHWRYRIGNYRVIAKIEDGTMVIILITIG
HRREVYRQSSARLI

Nucleotide

• Length: 285 bp

>T31357 NZ_AP017898:c2628127-2627843 [Sphingopyxis sp. FD7]
TTGGGCTGGACGCTTGAGGTTTCGGACCAGGCGCGTAAGCAGCTTCGCAAGATCGACATCAAGCAGGCGGATCGCATCAC
GCGGACGATGATTGATGTTGCACAGTTGGATGACCCCCGTCAGCGCGGTCATGCACTGGTTGGTGATTACGCGGGACATT
GGCGCTACCGCATCGGCAATTATCGGGTGATCGCAAAGATCGAGGATGGCACAATGGTGATTATATTGATCACCATCGGC
CATCGACGCGAGGTTTACCGCCAGAGCAGCGCGCGTTTAATCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8087.15 Da
• Isoelectric Point: 4.4076

>AT31357 WP_120220878.1 NZ_AP017898:c2628329-2628111 [Sphingopyxis sp. FD7]
MLAIRLDKELEDRLASAAKRSGRTKTALARKAIEEYIDDLEDIALLEEALADYDPSKNVSIEQVRRELGLDA

Nucleotide

• Length: 219 bp

>AT31357 NZ_AP017898:c2628329-2628111 [Sphingopyxis sp. FD7]
ATGCTCGCCATCCGCCTCGACAAGGAATTGGAAGATCGGCTCGCAAGTGCCGCGAAGCGGTCTGGCCGGACAAAAACCGC
TCTCGCCCGCAAAGCGATCGAGGAATATATCGACGATCTCGAAGACATAGCGCTACTCGAAGAAGCTTTGGCCGATTATG
ATCCAAGCAAGAATGTCTCGATCGAACAGGTAAGGCGGGAACTTGGGCTGGACGCTTGA