Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1845117..1845724 Replicon chromosome
Accession NZ_AP017898
Organism Sphingopyxis sp. FD7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SPYCA_RS08630 Protein ID WP_120219814.1
Coordinates 1845524..1845724 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SPYCA_RS08625 Protein ID WP_120219813.1
Coordinates 1845117..1845512 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPYCA_RS08595 1840477..1841439 + 963 WP_120222228.1 NAD(P)-binding protein -
SPYCA_RS08600 1841436..1842809 + 1374 WP_120219809.1 DNA photolyase family protein -
SPYCA_RS08605 1842905..1843459 + 555 WP_172595020.1 fasciclin domain-containing protein -
SPYCA_RS08610 1843516..1843941 - 426 WP_120219810.1 VOC family protein -
SPYCA_RS08615 1843994..1844617 - 624 WP_120219811.1 cation diffusion facilitator family transporter -
SPYCA_RS08620 1844687..1845097 + 411 WP_120219812.1 helix-turn-helix domain-containing protein -
SPYCA_RS08625 1845117..1845512 - 396 WP_120219813.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPYCA_RS08630 1845524..1845724 - 201 WP_120219814.1 type II toxin-antitoxin system HicA family toxin Toxin
SPYCA_RS08640 1846288..1846710 - 423 WP_120219815.1 large conductance mechanosensitive channel protein MscL -
SPYCA_RS08645 1846828..1847430 + 603 WP_120219816.1 LemA family protein -
SPYCA_RS08650 1847432..1848259 + 828 WP_172595022.1 TPM domain-containing protein -
SPYCA_RS08655 1848278..1848964 + 687 WP_120219817.1 hypothetical protein -
SPYCA_RS08660 1849067..1849609 + 543 WP_120219818.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(12-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-123)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7545.96 Da        Isoelectric Point: 11.7991

>T31354 WP_120219814.1 NZ_AP017898:c1845724-1845524 [Sphingopyxis sp. FD7]
MRIIIHMERDSRKIVRRLESEGYTLVATRGSHHKYRKGAVTIIVPHPRKDLPVGTARAIAKMAGWI

Download         Length: 201 bp

>T31354 NZ_AP017898:c1845724-1845524 [Sphingopyxis sp. FD7]
ATGCGTATTATTATACATATGGAGCGCGACAGCAGGAAGATTGTCCGGCGGTTGGAGAGTGAGGGATATACCCTCGTGGC
CACACGCGGCTCGCACCATAAATATCGAAAGGGCGCGGTCACGATCATCGTCCCGCATCCGAGGAAAGACCTGCCTGTCG
GCACCGCTCGTGCGATCGCCAAAATGGCGGGATGGATTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13913.64 Da        Isoelectric Point: 4.4818

>AT31354 WP_120219813.1 NZ_AP017898:c1845512-1845117 [Sphingopyxis sp. FD7]
MTHYIGVVHKDADSSYGIAFPDLPGCFSAGESLAELERNAIEALELFLDGEDVEAFPASDMTDIRAGLPEDDQGAMLMAV
PFVRSGGRTVRVNFTVDAATLAAIDAAAKRRKLSRSAFLVSAAHNEMSGAH

Download         Length: 396 bp

>AT31354 NZ_AP017898:c1845512-1845117 [Sphingopyxis sp. FD7]
ATGACCCACTATATCGGTGTCGTTCACAAGGATGCGGACAGCAGCTATGGCATCGCCTTTCCCGATCTTCCGGGCTGTTT
TTCGGCCGGGGAAAGCCTGGCCGAACTCGAACGCAATGCGATCGAGGCGCTGGAATTGTTTCTGGATGGCGAGGACGTCG
AGGCCTTTCCGGCCAGCGATATGACCGATATTCGAGCCGGCCTGCCGGAGGATGATCAGGGGGCCATGCTGATGGCCGTG
CCCTTCGTGCGTTCAGGCGGCCGGACCGTACGGGTGAACTTCACCGTCGATGCCGCGACGCTCGCGGCAATCGATGCCGC
CGCCAAGCGGCGCAAACTGTCCCGCAGCGCCTTTTTGGTCAGCGCGGCGCATAATGAGATGAGCGGAGCGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References