Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2212520..2213010 Replicon chromosome
Accession NZ_AP017896
Organism Actinomyces sp. Chiba101

Toxin (Protein)


Gene name relE Uniprot ID A0A1Q2TPW9
Locus tag CHIBA101_RS09135 Protein ID WP_073451135.1
Coordinates 2212520..2212789 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1Q2TQW2
Locus tag CHIBA101_RS09140 Protein ID WP_073451134.1
Coordinates 2212786..2213010 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHIBA101_RS09125 2207814..2211569 + 3756 WP_073451137.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
CHIBA101_RS09130 2211754..2212368 + 615 WP_073451136.1 lysophospholipase -
CHIBA101_RS09135 2212520..2212789 - 270 WP_073451135.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHIBA101_RS09140 2212786..2213010 - 225 WP_073451134.1 hypothetical protein Antitoxin
CHIBA101_RS09145 2213411..2213824 - 414 WP_077240150.1 mycothiol system anti-sigma-R factor -
CHIBA101_RS09150 2213824..2214426 - 603 WP_167370541.1 sigma-70 family RNA polymerase sigma factor -
CHIBA101_RS09155 2215033..2215488 + 456 WP_077239888.1 PadR family transcriptional regulator -
CHIBA101_RS09160 2215485..2216222 + 738 WP_077239887.1 hypothetical protein -
CHIBA101_RS09165 2216219..2216500 + 282 WP_073451129.1 PLD nuclease N-terminal domain-containing protein -
CHIBA101_RS09170 2216508..2217545 + 1038 WP_157750277.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(4-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10347.00 Da        Isoelectric Point: 10.4302

>T31353 WP_073451135.1 NZ_AP017896:c2212789-2212520 [Actinomyces sp. Chiba101]
MSYRLLYSKRADKQLAKMDRGTARVIVAWLNKNIDGAQDPRARGKALRGDLSGAWRYRIGDYRVLCDIHDEELIVLAIEI
GHRSMIYRR

Download         Length: 270 bp

>T31353 NZ_AP017896:c2212789-2212520 [Actinomyces sp. Chiba101]
ATGAGCTACCGGCTCCTCTACTCCAAGCGCGCCGACAAGCAGCTCGCCAAGATGGATCGCGGCACAGCCCGCGTTATTGT
CGCGTGGCTCAACAAGAATATCGATGGCGCTCAAGATCCCAGGGCGCGGGGGAAGGCGCTGCGCGGTGATCTGAGCGGGG
CGTGGAGGTACCGGATCGGCGACTACCGAGTGCTGTGCGACATCCATGACGAGGAGTTGATCGTCCTTGCCATCGAGATC
GGGCACCGTTCGATGATCTACCGGCGCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8297.20 Da        Isoelectric Point: 4.2213

>AT31353 WP_073451134.1 NZ_AP017896:c2213010-2212786 [Actinomyces sp. Chiba101]
MSTTSITLRLAAEEKTIIQDYASAFGQSLSEFMRTAALERIEDETDLKAWQEAREEHDADPVTVTADAMARKYA

Download         Length: 225 bp

>AT31353 NZ_AP017896:c2213010-2212786 [Actinomyces sp. Chiba101]
ATGAGCACGACGTCGATCACCCTGCGCCTGGCGGCGGAGGAGAAGACCATCATCCAGGATTACGCCTCGGCCTTCGGCCA
GAGCCTGTCCGAGTTCATGAGGACCGCGGCTCTGGAGCGCATCGAGGATGAGACCGATCTCAAGGCATGGCAGGAGGCGC
GAGAGGAGCACGATGCCGATCCCGTGACGGTCACCGCCGATGCGATGGCGCGCAAGTACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q2TPW9

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q2TQW2

References