Detailed information of TA system TA031343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2150985..2151517
• Replicon: chromosome
• Accession: NZ_AP017891
• Organism: Staphylococcus aureus strain GN3

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: CTB89_RS10905
• Protein ID: WP_001103944.1
• Coordinates: 2150985..2151305 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CTB89_RS10910
• Protein ID: WP_001058486.1
• Coordinates: 2151308..2151517 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTB89_RS10885	2146987..2147628	-	642	WP_020977425.1	mobile element-associated protein	-
CTB89_RS10890	2147625..2148005	-	381	WP_020977426.1	hypothetical protein	-
CTB89_RS10895	2148335..2150035	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
CTB89_RS10900	2150049..2150918	-	870	WP_086114945.1	primase alpha helix C-terminal domain-containing protein	-
CTB89_RS10905	2150985..2151305	-	321	WP_001103944.1	DUF1474 family protein	Toxin
CTB89_RS10910	2151308..2151517	-	210	WP_001058486.1	hypothetical protein	Antitoxin
CTB89_RS10915	2151510..2151656	-	147	WP_000708434.1	hypothetical protein	-
CTB89_RS10920	2151653..2151970	-	318	WP_020977427.1	helix-turn-helix domain-containing protein	-
CTB89_RS10925	2151975..2152193	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
CTB89_RS10930	2152366..2153040	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
CTB89_RS10935	2153054..2154226	+	1173	WP_000179346.1	site-specific integrase	-
CTB89_RS10940	2154295..2155911	-	1617	WP_120173204.1	chaperonin GroEL	-
CTB89_RS10945	2155987..2156271	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2138192..2156271	18079

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T31343 WP_001103944.1 NZ_AP017891:c2151305-2150985 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T31343 NZ_AP017891:c2151305-2150985 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT31343 WP_001058486.1 NZ_AP017891:c2151517-2151308 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT31343 NZ_AP017891:c2151517-2151308 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9