Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 936570..937047 Replicon chromosome
Accession NZ_AP017891
Organism Staphylococcus aureus strain GN3

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CTB89_RS04585 Protein ID WP_000052076.1
Coordinates 936570..936758 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CTB89_RS04590 Protein ID WP_001059690.1
Coordinates 936787..937047 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTB89_RS04555 932606..933078 + 473 Protein_843 hypothetical protein -
CTB89_RS04560 933419..934105 + 687 WP_001641381.1 thermonuclease family protein -
CTB89_RS04565 934462..934662 + 201 WP_001059082.1 cold-shock protein -
CTB89_RS04570 935160..935378 - 219 WP_000005880.1 hypothetical protein -
CTB89_RS04575 935441..935725 - 285 WP_001004401.1 hypothetical protein -
CTB89_RS04580 935813..936382 - 570 WP_020977093.1 hypothetical protein -
CTB89_RS04585 936570..936758 - 189 WP_000052076.1 hypothetical protein Toxin
CTB89_RS04590 936787..937047 - 261 WP_001059690.1 hypothetical protein Antitoxin
CTB89_RS04595 937387..937590 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CTB89_RS04600 937587..937823 - 237 WP_000368687.1 hypothetical protein -
CTB89_RS04605 938048..938629 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CTB89_RS04610 938702..939319 - 618 WP_020977094.1 LysE/ArgO family amino acid transporter -
CTB89_RS04615 939612..940106 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
CTB89_RS04620 940505..940927 - 423 WP_020977095.1 organic hydroperoxide resistance protein -
CTB89_RS04625 941075..941791 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T31336 WP_000052076.1 NZ_AP017891:c936758-936570 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T31336 NZ_AP017891:c936758-936570 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT31336 WP_001059690.1 NZ_AP017891:c937047-936787 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT31336 NZ_AP017891:c937047-936787 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References