Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 343877..344550 | Replicon | plasmid pSCLO_2 |
| Accession | NZ_AP017656 | ||
| Organism | Sphingobium cloacae strain JCM 10874 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A1E1F821 |
| Locus tag | SCLO_RS20295 | Protein ID | WP_048574953.1 |
| Coordinates | 343877..344290 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A0F7JTK4 |
| Locus tag | SCLO_RS20300 | Protein ID | WP_047100244.1 |
| Coordinates | 344287..344550 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SCLO_RS20275 | 339365..340342 | - | 978 | WP_048574804.1 | DUF2493 domain-containing protein | - |
| SCLO_RS20280 | 340822..341946 | + | 1125 | WP_066518892.1 | hypothetical protein | - |
| SCLO_RS20285 | 341996..342316 | - | 321 | WP_042469252.1 | single-stranded DNA-binding protein | - |
| SCLO_RS20290 | 342578..343780 | - | 1203 | WP_048574954.1 | SEC-C domain-containing protein | - |
| SCLO_RS20295 | 343877..344290 | - | 414 | WP_048574953.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SCLO_RS20300 | 344287..344550 | - | 264 | WP_047100244.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SCLO_RS20305 | 344738..345241 | - | 504 | WP_030541254.1 | DUF736 domain-containing protein | - |
| SCLO_RS20310 | 345405..345968 | - | 564 | WP_083949120.1 | MucR family transcriptional regulator | - |
| SCLO_RS20315 | 346146..346463 | - | 318 | WP_042469311.1 | hypothetical protein | - |
| SCLO_RS20320 | 346523..347221 | - | 699 | WP_066518895.1 | hypothetical protein | - |
| SCLO_RS20325 | 347211..347699 | - | 489 | WP_066518896.1 | hypothetical protein | - |
| SCLO_RS20330 | 347840..348169 | - | 330 | WP_066518897.1 | hypothetical protein | - |
| SCLO_RS20335 | 348166..348360 | - | 195 | WP_042469259.1 | hypothetical protein | - |
| SCLO_RS20340 | 348494..348826 | - | 333 | WP_066518898.1 | DUF3768 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..375493 | 375493 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14415.57 Da Isoelectric Point: 5.6141
>T31331 WP_048574953.1 NZ_AP017656:c344290-343877 [Sphingobium cloacae]
VTQLYMLDTNIVSELARNPHGAVATRIAQVGADAICVSIITAAELRYGCAKKGSPRLLAQMEAILGSVSVLALDVPADTE
YGGIRAELESAGKPIGPNDLFIAAHAYALGATLVTANIGEFSRVRALKVENWLSDVH
VTQLYMLDTNIVSELARNPHGAVATRIAQVGADAICVSIITAAELRYGCAKKGSPRLLAQMEAILGSVSVLALDVPADTE
YGGIRAELESAGKPIGPNDLFIAAHAYALGATLVTANIGEFSRVRALKVENWLSDVH
Download Length: 414 bp
>T31331 NZ_AP017656:c344290-343877 [Sphingobium cloacae]
GTGACCCAGCTCTACATGCTCGATACCAACATCGTGTCGGAACTCGCGCGAAACCCGCACGGCGCCGTAGCCACCCGGAT
CGCGCAAGTCGGTGCCGATGCGATTTGCGTCAGCATCATCACCGCGGCCGAGCTGCGCTACGGCTGCGCGAAGAAGGGGT
CCCCCAGGCTCCTGGCCCAAATGGAGGCGATCCTCGGCAGCGTGTCCGTGCTTGCGCTCGATGTCCCGGCGGACACTGAA
TATGGCGGTATCCGAGCCGAGCTGGAGAGCGCGGGCAAACCCATCGGGCCCAACGACCTCTTCATCGCGGCTCATGCCTA
TGCGCTCGGCGCCACATTGGTGACCGCCAACATCGGCGAGTTCTCCCGCGTCCGGGCCCTCAAGGTGGAGAATTGGCTGA
GCGACGTCCATTGA
GTGACCCAGCTCTACATGCTCGATACCAACATCGTGTCGGAACTCGCGCGAAACCCGCACGGCGCCGTAGCCACCCGGAT
CGCGCAAGTCGGTGCCGATGCGATTTGCGTCAGCATCATCACCGCGGCCGAGCTGCGCTACGGCTGCGCGAAGAAGGGGT
CCCCCAGGCTCCTGGCCCAAATGGAGGCGATCCTCGGCAGCGTGTCCGTGCTTGCGCTCGATGTCCCGGCGGACACTGAA
TATGGCGGTATCCGAGCCGAGCTGGAGAGCGCGGGCAAACCCATCGGGCCCAACGACCTCTTCATCGCGGCTCATGCCTA
TGCGCTCGGCGCCACATTGGTGACCGCCAACATCGGCGAGTTCTCCCGCGTCCGGGCCCTCAAGGTGGAGAATTGGCTGA
GCGACGTCCATTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9838.22 Da Isoelectric Point: 4.7010
>AT31331 WP_047100244.1 NZ_AP017656:c344550-344287 [Sphingobium cloacae]
VTPDHEATVTREAKLFRNNKSQAVRIPADFELPGDRVMIHREGDRLVIEPIRRRNIVEVLASLEPLGPEDEFPDIDSTLL
PAKAIEL
VTPDHEATVTREAKLFRNNKSQAVRIPADFELPGDRVMIHREGDRLVIEPIRRRNIVEVLASLEPLGPEDEFPDIDSTLL
PAKAIEL
Download Length: 264 bp
>AT31331 NZ_AP017656:c344550-344287 [Sphingobium cloacae]
GTGACGCCCGATCATGAAGCAACGGTCACCAGAGAAGCGAAGCTGTTCCGCAACAACAAGAGCCAGGCAGTGCGCATCCC
GGCCGATTTCGAGCTGCCTGGAGATCGGGTCATGATCCACCGGGAGGGAGATCGACTGGTCATCGAGCCGATCCGCCGCC
GAAACATCGTTGAGGTCCTTGCGAGCCTCGAACCCCTTGGCCCCGAGGATGAATTCCCGGACATCGACAGCACCTTGCTT
CCGGCCAAGGCCATCGAATTGTGA
GTGACGCCCGATCATGAAGCAACGGTCACCAGAGAAGCGAAGCTGTTCCGCAACAACAAGAGCCAGGCAGTGCGCATCCC
GGCCGATTTCGAGCTGCCTGGAGATCGGGTCATGATCCACCGGGAGGGAGATCGACTGGTCATCGAGCCGATCCGCCGCC
GAAACATCGTTGAGGTCCTTGCGAGCCTCGAACCCCTTGGCCCCGAGGATGAATTCCCGGACATCGACAGCACCTTGCTT
CCGGCCAAGGCCATCGAATTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E1F821 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F7JTK4 |