31330

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3159423..3160026 Replicon chromosome
Accession NZ_AP017655
Organism Sphingobium cloacae strain JCM 10874

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag SCLO_RS15455 Protein ID WP_066519793.1
Coordinates 3159736..3160026 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag SCLO_RS15450 Protein ID WP_066519673.1
Coordinates 3159423..3159710 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCLO_RS15430 3154541..3155383 - 843 WP_066519686.1 GPO family capsid scaffolding protein -
SCLO_RS15435 3155587..3157398 + 1812 WP_066519683.1 terminase family protein -
SCLO_RS15440 3157395..3158444 + 1050 WP_066519682.1 phage portal protein -
SCLO_RS15445 3158594..3159403 + 810 WP_066519675.1 DNA adenine methylase -
SCLO_RS15450 3159423..3159710 - 288 WP_066519673.1 putative addiction module antidote protein Antitoxin
SCLO_RS15455 3159736..3160026 - 291 WP_066519793.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SCLO_RS15460 3160097..3160402 - 306 WP_066519670.1 hypothetical protein -
SCLO_RS23455 3160399..3160566 - 168 WP_169800571.1 hypothetical protein -
SCLO_RS15465 3161119..3161802 - 684 WP_066519668.1 hypothetical protein -
SCLO_RS15475 3162069..3162785 + 717 WP_066519667.1 queuosine precursor transporter -
SCLO_RS15480 3162782..3163522 - 741 WP_066519663.1 tRNA pseudouridine(38-40) synthase TruA -
SCLO_RS15485 3163519..3164436 - 918 WP_066519656.1 methionyl-tRNA formyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3125984..3168530 42546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-88)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10674.23 Da        Isoelectric Point: 10.6052

>T31330 WP_066519793.1 NZ_AP017655:c3160026-3159736 [Sphingobium cloacae]
METQQTPAFADWFDGLRDRKAKSKIAGRIARFELGLMGDVKSVGDGVSEARIDFGPGYRLYFTRRGNRLIVLLVGGDKST
QQRDIARAKDMAAQIP

Download         Length: 291 bp

>T31330 NZ_AP017655:c3160026-3159736 [Sphingobium cloacae]
ATGGAAACGCAGCAAACCCCCGCTTTCGCCGACTGGTTCGACGGCCTTCGCGACCGCAAGGCCAAGTCGAAGATCGCGGG
GCGCATCGCCCGCTTCGAACTCGGCCTGATGGGCGACGTGAAATCGGTGGGCGATGGCGTTTCGGAAGCGCGTATCGACT
TCGGCCCCGGATACCGCCTCTATTTCACCCGCCGGGGCAACAGGCTGATCGTCCTGCTGGTGGGCGGCGACAAGTCCACC
CAGCAGCGGGACATAGCAAGGGCAAAGGACATGGCGGCCCAGATACCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10160.76 Da        Isoelectric Point: 4.7513

>AT31330 WP_066519673.1 NZ_AP017655:c3159710-3159423 [Sphingobium cloacae]
MTIELSRFDAAQYLTEPEDQAELLADAVATGDAQIIAKAIGIVARAHGMVELSKETGLNRQQLYRALGPEGNPTLATMLK
VLPALGLRMRIEAAA

Download         Length: 288 bp

>AT31330 NZ_AP017655:c3159710-3159423 [Sphingobium cloacae]
ATGACTATCGAACTCAGCCGCTTCGACGCGGCTCAATATCTGACCGAACCGGAGGACCAGGCCGAACTGCTGGCCGATGC
CGTCGCGACCGGCGATGCCCAGATCATCGCCAAGGCTATCGGCATCGTCGCCCGCGCGCATGGCATGGTGGAACTGTCCA
AGGAAACCGGCCTCAACCGGCAGCAGCTTTATCGCGCGCTGGGGCCGGAAGGCAATCCGACGCTGGCGACCATGCTGAAG
GTGCTGCCCGCGCTTGGCCTGCGGATGCGGATAGAGGCGGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References