31329

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1794120..1794793 Replicon chromosome
Accession NZ_AP017655
Organism Sphingobium cloacae strain JCM 10874

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E1F253
Locus tag SCLO_RS08755 Protein ID WP_066522444.1
Coordinates 1794120..1794542 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SCLO_RS08760 Protein ID WP_066522447.1
Coordinates 1794539..1794793 (-) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SCLO_RS08725 1790291..1791019 + 729 WP_096362194.1 IS21-like element helper ATPase IstB -
SCLO_RS08730 1791263..1791565 - 303 WP_083949273.1 DUF2285 domain-containing protein -
SCLO_RS08735 1791620..1791886 - 267 WP_045811379.1 helix-turn-helix transcriptional regulator -
SCLO_RS08740 1792194..1792520 - 327 WP_041535876.1 DUF736 domain-containing protein -
SCLO_RS08750 1793093..1793533 - 441 WP_066522441.1 hypothetical protein -
SCLO_RS23310 1793671..1793838 - 168 WP_169800605.1 hypothetical protein -
SCLO_RS08755 1794120..1794542 - 423 WP_066522444.1 type II toxin-antitoxin system VapC family toxin Toxin
SCLO_RS08760 1794539..1794793 - 255 WP_066522447.1 plasmid stabilization protein Antitoxin
SCLO_RS08765 1794880..1795806 - 927 WP_096362113.1 DUF2493 domain-containing protein -
SCLO_RS08770 1796155..1797192 - 1038 WP_066522394.1 toprim domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-124)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 141 a.a.        Molecular weight: 15039.28 Da        Isoelectric Point: 4.5187

>T31329 WP_066522444.1 NZ_AP017655:c1794542-1794120 [Sphingobium cloacae]
MILLDTNVVSEVMKPAPDEAVRAWLDEQVAETLFLSSVTIAELMFGIGALPEGKRKERLTEALDGVMELFADRILPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDNSAFEAANVTVIDPWKAGR

Download         Length: 423 bp

>T31329 NZ_AP017655:c1794542-1794120 [Sphingobium cloacae]
ATGATCCTCCTCGATACCAATGTCGTATCGGAGGTGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGTAGCGGAAACGCTCTTTCTCTCCAGCGTCACCATCGCCGAGCTGATGTTCGGCATCGGCGCGCTCCCCGAGGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCATCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGGGCGGCCGGCAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATCGCAGCCGCCAAGGGTTTTGCCGTCGCCACGCGCGACAACAGCGCATTCGAGGCCGCGAATGTCACGGTCATCG
ATCCCTGGAAGGCCGGGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9323.68 Da        Isoelectric Point: 9.0128

>AT31329 WP_066522447.1 NZ_AP017655:c1794793-1794539 [Sphingobium cloacae]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDPARDMAPAKP
MSFE

Download         Length: 255 bp

>AT31329 NZ_AP017655:c1794793-1794539 [Sphingobium cloacae]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCACCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTTCGTCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCCGGCTCGTGACATGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1E1F253


Antitoxin

Source ID Structure

References