Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 1794120..1794793 | Replicon | chromosome |
Accession | NZ_AP017655 | ||
Organism | Sphingobium cloacae strain JCM 10874 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A1E1F253 |
Locus tag | SCLO_RS08755 | Protein ID | WP_066522444.1 |
Coordinates | 1794120..1794542 (-) | Length | 141 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | SCLO_RS08760 | Protein ID | WP_066522447.1 |
Coordinates | 1794539..1794793 (-) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SCLO_RS08725 | 1790291..1791019 | + | 729 | WP_096362194.1 | IS21-like element helper ATPase IstB | - |
SCLO_RS08730 | 1791263..1791565 | - | 303 | WP_083949273.1 | DUF2285 domain-containing protein | - |
SCLO_RS08735 | 1791620..1791886 | - | 267 | WP_045811379.1 | helix-turn-helix transcriptional regulator | - |
SCLO_RS08740 | 1792194..1792520 | - | 327 | WP_041535876.1 | DUF736 domain-containing protein | - |
SCLO_RS08750 | 1793093..1793533 | - | 441 | WP_066522441.1 | hypothetical protein | - |
SCLO_RS23310 | 1793671..1793838 | - | 168 | WP_169800605.1 | hypothetical protein | - |
SCLO_RS08755 | 1794120..1794542 | - | 423 | WP_066522444.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
SCLO_RS08760 | 1794539..1794793 | - | 255 | WP_066522447.1 | plasmid stabilization protein | Antitoxin |
SCLO_RS08765 | 1794880..1795806 | - | 927 | WP_096362113.1 | DUF2493 domain-containing protein | - |
SCLO_RS08770 | 1796155..1797192 | - | 1038 | WP_066522394.1 | toprim domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 15039.28 Da Isoelectric Point: 4.5187
>T31329 WP_066522444.1 NZ_AP017655:c1794542-1794120 [Sphingobium cloacae]
MILLDTNVVSEVMKPAPDEAVRAWLDEQVAETLFLSSVTIAELMFGIGALPEGKRKERLTEALDGVMELFADRILPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDNSAFEAANVTVIDPWKAGR
MILLDTNVVSEVMKPAPDEAVRAWLDEQVAETLFLSSVTIAELMFGIGALPEGKRKERLTEALDGVMELFADRILPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDNSAFEAANVTVIDPWKAGR
Download Length: 423 bp
>T31329 NZ_AP017655:c1794542-1794120 [Sphingobium cloacae]
ATGATCCTCCTCGATACCAATGTCGTATCGGAGGTGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGTAGCGGAAACGCTCTTTCTCTCCAGCGTCACCATCGCCGAGCTGATGTTCGGCATCGGCGCGCTCCCCGAGGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCATCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGGGCGGCCGGCAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATCGCAGCCGCCAAGGGTTTTGCCGTCGCCACGCGCGACAACAGCGCATTCGAGGCCGCGAATGTCACGGTCATCG
ATCCCTGGAAGGCCGGGCGCTGA
ATGATCCTCCTCGATACCAATGTCGTATCGGAGGTGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGTAGCGGAAACGCTCTTTCTCTCCAGCGTCACCATCGCCGAGCTGATGTTCGGCATCGGCGCGCTCCCCGAGGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCATCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGGGCGGCCGGCAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATCGCAGCCGCCAAGGGTTTTGCCGTCGCCACGCGCGACAACAGCGCATTCGAGGCCGCGAATGTCACGGTCATCG
ATCCCTGGAAGGCCGGGCGCTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9323.68 Da Isoelectric Point: 9.0128
>AT31329 WP_066522447.1 NZ_AP017655:c1794793-1794539 [Sphingobium cloacae]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDPARDMAPAKP
MSFE
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDPARDMAPAKP
MSFE
Download Length: 255 bp
>AT31329 NZ_AP017655:c1794793-1794539 [Sphingobium cloacae]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCACCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTTCGTCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCCGGCTCGTGACATGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCACCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTTCGTCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCCGGCTCGTGACATGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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