Detailed information of TA system TA031325

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 734854..736100
• Replicon: chromosome
• Accession: NZ_AP017652
• Organism: Streptococcus sp. NPS 308

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: SNAG_RS03905
• Protein ID: WP_096406728.1
• Coordinates: 735330..736100 (+)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: SNAG_RS03900
• Protein ID: WP_096406725.1
• Coordinates: 734854..735330 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SNAG_RS03860	731111..731395	+	285	WP_007520203.1	hypothetical protein	-
SNAG_RS03865	731409..731705	+	297	WP_096406718.1	hypothetical protein	-
SNAG_RS03870	731719..731916	-	198	WP_004249782.1	hypothetical protein	-
SNAG_RS03875	732076..732717	+	642	WP_037619220.1	hypothetical protein	-
SNAG_RS03880	732727..733812	+	1086	WP_096406720.1	toprim domain-containing protein	-
SNAG_RS03885	733863..734096	+	234	WP_000152419.1	hypothetical protein	-
SNAG_RS03890	734093..734476	+	384	WP_000159223.1	hypothetical protein	-
SNAG_RS03895	734514..734786	+	273	WP_096406723.1	hypothetical protein	-
SNAG_RS03900	734854..735330	+	477	WP_096406725.1	helix-turn-helix domain-containing protein	Antitoxin
SNAG_RS03905	735330..736100	+	771	WP_096406728.1	zeta toxin family protein	Toxin
SNAG_RS03915	736726..737568	-	843	WP_096406733.1	Rgg/GadR/MutR family transcriptional regulator	-
SNAG_RS03920	737959..739170	+	1212	WP_096406736.1	MFS transporter	-
SNAG_RS03925	739297..739635	-	339	WP_157740110.1	winged helix-turn-helix domain-containing protein	-
SNAG_RS03930	740041..740937	-	897	WP_096406741.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	701345..768478	67133
	-	flank	IS/Tn	-	-	739297..739602	305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29429.34 Da
• Isoelectric Point: 6.1704

>T31325 WP_096406728.1 NZ_AP017652:735330-736100 [Streptococcus sp. NPS 308]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSQLGYNLLIEGTLRTVDVPKKTTQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVYHLVDNTRQLEELAIFERIQIYQRDRSCVYDSGEDIISAAKVLQEYLFGKWSKVEEEML
KVGEERLEDLTNRNDC

Nucleotide

• Length: 771 bp

>T31325 NZ_AP017652:735330-736100 [Streptococcus sp. NPS 308]
GTGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTTGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
ATTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACCACACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCAGAGTTATCCTATCTCAGTACCTTAATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTATATCATCTAGTTGATAA
TACACGACAATTGGAAGAATTGGCTATCTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAG
GAGAAGATATAATTTCAGCAGCAAAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGTGGGAGAAGAAAGATTGGAAGATTTAACTAATCGAAATGATTGTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18247.72 Da
• Isoelectric Point: 4.4188

>AT31325 WP_096406725.1 NZ_AP017652:734854-735330 [Streptococcus sp. NPS 308]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGICIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT31325 NZ_AP017652:734854-735330 [Streptococcus sp. NPS 308]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCCCGGATTGTAGGTATTTC
TCGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGACAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCACGACTCTATCGTTATCAAGATAGTCAGGGAATTTGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG