Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1239293..1239873 Replicon chromosome
Accession NZ_AP017649
Organism Dehalococcoides mccartyi strain UCH-ATV1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DEHALATV1_RS06610 Protein ID WP_096476960.1
Coordinates 1239293..1239637 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DEHALATV1_RS06615 Protein ID WP_096476961.1
Coordinates 1239631..1239873 (-) Length 81 a.a.

Genomic Context

DEHALATV1_RS06600DEHALATV1_RS06605DEHALATV1_RS06620DEHALATV1_RS06640DEHALATV1_RS06650DEHALATV1_RS06575DEHALATV1_RS06580DEHALATV1_RS06585DEHALATV1_RS06590DEHALATV1_RS06595DEHALATV1_RS07560DEHALATV1_RS06610DEHALATV1_RS06615DEHALATV1_RS06625DEHALATV1_RS06630DEHALATV1_RS06645
Location: 1238217..1238678 (462 bp)
Type: Others
Protein ID: WP_096476958.1
Location: 1238762..1239214 (453 bp)
Type: Others
Protein ID: WP_146048216.1
Location: 1240166..1241152 (987 bp)
Type: Others
Protein ID: Protein_1274
Location: 1243057..1243560 (504 bp)
Type: Others
Protein ID: WP_096476964.1
Location: 1244106..1244576 (471 bp)
Type: Others
Protein ID: WP_096476966.1
Location: 1234494..1236146 (1653 bp)
Type: Others
Protein ID: WP_096476955.1
Location: 1236133..1236360 (228 bp)
Type: Others
Protein ID: WP_096476956.1
Location: 1236378..1236572 (195 bp)
Type: Others
Protein ID: WP_023652786.1
Location: 1236577..1237200 (624 bp)
Type: Others
Protein ID: WP_096476957.1
Location: 1237187..1237900 (714 bp)
Type: Others
Protein ID: WP_023652788.1
Location: 1237960..1238127 (168 bp)
Type: Others
Protein ID: WP_155760401.1
Location: 1239293..1239637 (345 bp)
Type: Toxin
Protein ID: WP_096476960.1
Location: 1239631..1239873 (243 bp)
Type: Antitoxin
Protein ID: WP_096476961.1
Location: 1241263..1241673 (411 bp)
Type: Others
Protein ID: Protein_1275
Location: 1241896..1242390 (495 bp)
Type: Others
Protein ID: WP_096476962.1
Location: 1243655..1243933 (279 bp)
Type: Others
Protein ID: Protein_1278
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DEHALATV1_RS065751234494..1236146-1653WP_096476955.1recombinase family protein-
DEHALATV1_RS065801236133..1236360-228WP_096476956.1hypothetical protein-
DEHALATV1_RS065851236378..1236572-195WP_023652786.1hypothetical protein-
DEHALATV1_RS065901236577..1237200-624WP_096476957.1ParB N-terminal domain-containing protein-
DEHALATV1_RS065951237187..1237900-714WP_023652788.1hypothetical protein-
DEHALATV1_RS075601237960..1238127-168WP_155760401.1hypothetical protein-
DEHALATV1_RS066001238217..1238678+462WP_096476958.1hypothetical protein-
DEHALATV1_RS066051238762..1239214+453WP_146048216.1hypothetical protein-
DEHALATV1_RS066101239293..1239637-345WP_096476960.1endoribonuclease MazFToxin
DEHALATV1_RS066151239631..1239873-243WP_096476961.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
DEHALATV1_RS066201240166..1241152+987Protein_1274precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE-
DEHALATV1_RS066251241263..1241673-411Protein_1275recombinase family protein-
DEHALATV1_RS066301241896..1242390-495WP_096476962.1hypothetical protein-
DEHALATV1_RS066401243057..1243560+504WP_096476964.1NUDIX domain-containing protein-
DEHALATV1_RS066451243655..1243933-279Protein_1278recombinase family protein-
DEHALATV1_RS066501244106..1244576+471WP_096476966.1zinc ribbon domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--1190790..124335052560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-111)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12413.38 Da        Isoelectric Point: 7.1052

>T31324 WP_096476960.1 NZ_AP017649:c1239637-1239293 [Dehalococcoides mccartyi]
MVNRDYIPQCGDAVRISLNPQAGHEQAGRRPAVVLSPRSYNGKTGLAILCPITRHIKGYPFEVVLPDGLSVSGAILSDQV
KSLDWRVRDAELICTLSDEVISEIMQKLGALLSI

Download         Length: 345 bp

>T31324 NZ_AP017649:c1239637-1239293 [Dehalococcoides mccartyi]
ATGGTAAACAGGGATTATATTCCTCAATGCGGGGATGCGGTGCGCATCAGCTTAAATCCGCAGGCAGGCCATGAGCAAGC
CGGGCGCCGTCCCGCCGTCGTGCTCTCCCCGCGAAGCTATAACGGCAAGACAGGGCTTGCTATCCTATGTCCCATTACCA
GGCATATTAAAGGCTATCCCTTCGAGGTAGTGCTTCCTGATGGTTTATCGGTATCTGGAGCAATACTATCCGATCAGGTG
AAGAGCTTAGACTGGCGTGTTCGCGATGCGGAACTGATATGTACCTTATCGGATGAAGTTATCTCGGAGATAATGCAGAA
GCTGGGGGCTCTTTTATCGATATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8716.14 Da        Isoelectric Point: 8.6020

>AT31324 WP_096476961.1 NZ_AP017649:c1239873-1239631 [Dehalococcoides mccartyi]
MKTLVQKWGNSLALRIPKVFAAEVGLQKETSVEVSLTDGKLIITPVSQPKLTLQQLLAKITKYNLHSEVDTGPAAGDEAW

Download         Length: 243 bp

>AT31324 NZ_AP017649:c1239873-1239631 [Dehalococcoides mccartyi]
ATGAAAACCCTTGTTCAGAAATGGGGGAACAGTCTTGCCTTACGTATCCCCAAAGTATTCGCTGCTGAGGTAGGACTTCA
AAAAGAAACATCTGTTGAAGTGTCGTTGACGGACGGCAAGCTTATTATTACTCCGGTATCTCAACCGAAGCTGACACTTC
AACAGCTCCTGGCAAAGATTACCAAATATAATCTGCACAGTGAAGTTGATACCGGCCCTGCTGCGGGGGACGAAGCATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References