Detailed information of TA system TA031318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1507647..1508259
• Replicon: chromosome
• Accession: NZ_AP017629
• Organism: Streptococcus pyogenes strain JMUB1235

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JMUB1235_RS07575
• Protein ID: WP_002994716.1
• Coordinates: 1507924..1508259 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: JMUB1235_RS07570
• Protein ID: WP_002988079.1
• Coordinates: 1507647..1507934 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMUB1235_RS07545	1502837..1503820	-	984	WP_031488719.1	tagatose-bisphosphate aldolase	-
JMUB1235_RS07550	1503824..1504753	-	930	WP_031488720.1	tagatose-6-phosphate kinase	-
JMUB1235_RS07555	1504801..1505316	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
JMUB1235_RS07560	1505351..1505779	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
JMUB1235_RS07565	1506224..1506997	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
JMUB1235_RS07570	1507647..1507934	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
JMUB1235_RS07575	1507924..1508259	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMUB1235_RS08845	1508411..1508881	+	471	WP_021733374.1	site-specific integrase	-
JMUB1235_RS08850	1508844..1509392	+	549	WP_180372715.1	site-specific integrase	-
JMUB1235_RS07585	1509524..1509916	-	393	WP_002982716.1	30S ribosomal protein S9	-
JMUB1235_RS07590	1509937..1510383	-	447	WP_002982710.1	50S ribosomal protein L13	-
JMUB1235_RS07595	1510601..1510807	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
JMUB1235_RS07600	1510804..1511310	-	507	WP_002988070.1	hypothetical protein	-
JMUB1235_RS07605	1511446..1512306	-	861	WP_011529009.1	DegV family protein	-
JMUB1235_RS07610	1512403..1512921	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T31318 WP_002994716.1 NZ_AP017629:1507924-1508259 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T31318 NZ_AP017629:1507924-1508259 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT31318 WP_002988079.1 NZ_AP017629:1507647-1507934 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT31318 NZ_AP017629:1507647-1507934 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94