Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 52462..52984 | Replicon | plasmid pMRY15-131_2 |
| Accession | NZ_AP017622 | ||
| Organism | Escherichia coli strain MRY15-131 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | CPY99_RS26685 | Protein ID | WP_000638823.1 |
| Coordinates | 52462..52743 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | CPY99_RS26690 | Protein ID | WP_000121741.1 |
| Coordinates | 52733..52984 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPY99_RS26650 | 48611..48931 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| CPY99_RS26655 | 49002..49190 | - | 189 | WP_050567133.1 | hypothetical protein | - |
| CPY99_RS26660 | 49292..49876 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| CPY99_RS26665 | 49897..50295 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| CPY99_RS26670 | 50414..50851 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| CPY99_RS26675 | 50857..52092 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| CPY99_RS26680 | 52095..52394 | - | 300 | WP_000835764.1 | IncN plasmid KikA protein | - |
| CPY99_RS26685 | 52462..52743 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPY99_RS26690 | 52733..52984 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| CPY99_RS26695 | 53084..53719 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| CPY99_RS26700 | 53792..54079 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| CPY99_RS26705 | 54092..54346 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| CPY99_RS26710 | 54348..54989 | - | 642 | WP_001425343.1 | conjugal transfer protein TrbJ | - |
| CPY99_RS26715 | 54995..55990 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| CPY99_RS26720 | 55994..56251 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| CPY99_RS26725 | 56248..56550 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| CPY99_RS26730 | 56531..56788 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| CPY99_RS26735 | 56821..57267 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| CPY99_RS27280 | 57278..57448 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| CPY99_RS26740 | 57452..57895 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60722 | 60722 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T31301 WP_000638823.1 NZ_AP017622:c52743-52462 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T31301 NZ_AP017622:c52743-52462 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT31301 WP_000121741.1 NZ_AP017622:c52984-52733 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT31301 NZ_AP017622:c52984-52733 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|