Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
Location | 7527..8028 | Replicon | plasmid pMRY15-131_2 |
Accession | NZ_AP017622 | ||
Organism | Escherichia coli strain MRY15-131 |
Toxin (Protein)
Gene name | TsxA | Uniprot ID | H1ZXU8 |
Locus tag | CPY99_RS26430 | Protein ID | WP_000702247.1 |
Coordinates | 7527..7787 (+) | Length | 87 a.a. |
Antitoxin (Protein)
Gene name | TsxB | Uniprot ID | - |
Locus tag | CPY99_RS26435 | Protein ID | WP_001132407.1 |
Coordinates | 7777..8028 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CPY99_RS26380 | 3123..3284 | + | 162 | WP_000775236.1 | type I toxin-antitoxin system Hok family toxin | - |
CPY99_RS26385 | 3434..4030 | + | 597 | WP_000125165.1 | hypothetical protein | - |
CPY99_RS27335 | 4048..4332 | - | 285 | WP_001162371.1 | hypothetical protein | - |
CPY99_RS26395 | 4406..5071 | - | 666 | WP_000532148.1 | P-loop NTPase | - |
CPY99_RS26405 | 5669..5998 | + | 330 | WP_000855120.1 | hypothetical protein | - |
CPY99_RS26415 | 6580..6903 | + | 324 | WP_000427403.1 | hypothetical protein | - |
CPY99_RS26420 | 6945..7154 | + | 210 | WP_000866036.1 | hypothetical protein | - |
CPY99_RS26425 | 7251..7475 | + | 225 | WP_000814381.1 | hypothetical protein | - |
CPY99_RS26430 | 7527..7787 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
CPY99_RS26435 | 7777..8028 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
CPY99_RS26450 | 8578..8856 | + | 279 | WP_000545938.1 | hypothetical protein | - |
CPY99_RS26455 | 9276..9542 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
CPY99_RS26460 | 9649..9831 | - | 183 | WP_001481829.1 | hypothetical protein | - |
CPY99_RS26465 | 10389..10571 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
CPY99_RS26470 | 10596..11033 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
CPY99_RS26475 | 11164..11490 | - | 327 | WP_063078684.1 | hypothetical protein | - |
CPY99_RS26480 | 11510..12217 | - | 708 | WP_021503228.1 | hypothetical protein | - |
CPY99_RS26485 | 12219..12971 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60722 | 60722 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T31300 WP_000702247.1 NZ_AP017622:7527-7787 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T31300 NZ_AP017622:7527-7787 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT31300 WP_001132407.1 NZ_AP017622:7777-8028 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT31300 NZ_AP017622:7777-8028 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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