Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3248000..3248835 | Replicon | chromosome |
| Accession | NZ_AP017620 | ||
| Organism | Escherichia coli strain MRY15-131 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1V1GYU4 |
| Locus tag | CPY99_RS16280 | Protein ID | WP_000854719.1 |
| Coordinates | 3248458..3248835 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | CPY99_RS16275 | Protein ID | WP_001285113.1 |
| Coordinates | 3248000..3248368 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPY99_RS16230 | 3243541..3243774 | + | 234 | WP_001278282.1 | DUF905 family protein | - |
| CPY99_RS16235 | 3243864..3244208 | + | 345 | Protein_3019 | DUF932 domain-containing protein | - |
| CPY99_RS16245 | 3245449..3245943 | + | 495 | Protein_3021 | DUF932 domain-containing protein | - |
| CPY99_RS16250 | 3246020..3246505 | + | 486 | WP_000213705.1 | antirestriction protein | - |
| CPY99_RS16260 | 3246521..3246997 | + | 477 | WP_001186715.1 | RadC family protein | - |
| CPY99_RS16265 | 3247066..3247287 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| CPY99_RS16270 | 3247306..3247950 | + | 645 | WP_000086770.1 | hypothetical protein | - |
| CPY99_RS16275 | 3248000..3248368 | + | 369 | WP_001285113.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CPY99_RS16280 | 3248458..3248835 | + | 378 | WP_000854719.1 | TA system toxin CbtA family protein | Toxin |
| CPY99_RS16285 | 3248832..3249320 | + | 489 | WP_000761679.1 | hypothetical protein | - |
| CPY99_RS16290 | 3249338..3249535 | + | 198 | WP_000839266.1 | DUF957 domain-containing protein | - |
| CPY99_RS16295 | 3249620..3250465 | + | 846 | WP_001440175.1 | DUF4942 domain-containing protein | - |
| CPY99_RS16300 | 3250534..3250929 | + | 396 | WP_000208386.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| CPY99_RS16305 | 3250922..3251869 | + | 948 | WP_001440173.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| CPY99_RS16310 | 3252273..3253538 | + | 1266 | WP_096427322.1 | integrase arm-type DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sfaX | 3242030..3279003 | 36973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14059.10 Da Isoelectric Point: 8.2904
>T31281 WP_000854719.1 NZ_AP017620:3248458-3248835 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T31281 NZ_AP017620:3248458-3248835 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13693.33 Da Isoelectric Point: 5.4970
>AT31281 WP_001285113.1 NZ_AP017620:3248000-3248368 [Escherichia coli]
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKT
Download Length: 369 bp
>AT31281 NZ_AP017620:3248000-3248368 [Escherichia coli]
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|