Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 897527..898232 Replicon chromosome
Accession NZ_AP017620
Organism Escherichia coli strain MRY15-131

Toxin (Protein)


Gene name relE Uniprot ID A0A1M2J6W7
Locus tag CPY99_RS04625 Protein ID WP_000539524.1
Coordinates 897846..898232 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CPY99_RS04620 Protein ID WP_001280945.1
Coordinates 897527..897856 (-) Length 110 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPY99_RS04605 892696..893607 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
CPY99_RS04610 893784..896132 + 2349 WP_000950331.1 EAL domain-containing protein -
CPY99_RS04615 896140..897457 + 1318 Protein_846 diguanylate cyclase -
CPY99_RS04620 897527..897856 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
CPY99_RS04625 897846..898232 - 387 WP_000539524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPY99_RS04630 898458..899783 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
CPY99_RS04635 899996..900379 + 384 WP_000497137.1 biofilm formation regulator BssR -
CPY99_RS04640 900490..901605 + 1116 WP_000555056.1 aldose sugar dehydrogenase YliI -
CPY99_RS04645 901602..902228 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-124)

Antitoxin

(53-94)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14321.46 Da        Isoelectric Point: 9.9521

>T31267 WP_000539524.1 NZ_AP017620:c898232-897846 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T31267 NZ_AP017620:c898232-897846 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAAGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAGGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT31267 WP_001280945.1 NZ_AP017620:c897856-897527 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT31267 NZ_AP017620:c897856-897527 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1M2J6W7


Antitoxin

Source ID Structure

References