Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 52963..53485 | Replicon | plasmid pMRY15-117_2 |
| Accession | NZ_AP017619 | ||
| Organism | Escherichia coli strain MRY15-117 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | CPZ03_RS27075 | Protein ID | WP_000638823.1 |
| Coordinates | 52963..53244 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | CPZ03_RS27080 | Protein ID | WP_000121741.1 |
| Coordinates | 53234..53485 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ03_RS27040 | 49112..49432 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| CPZ03_RS27045 | 49503..49691 | - | 189 | WP_050567133.1 | hypothetical protein | - |
| CPZ03_RS27050 | 49793..50377 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| CPZ03_RS27055 | 50398..50796 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| CPZ03_RS27060 | 50915..51352 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| CPZ03_RS27065 | 51358..52593 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| CPZ03_RS27070 | 52596..52895 | - | 300 | WP_000835764.1 | IncN plasmid KikA protein | - |
| CPZ03_RS27075 | 52963..53244 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ03_RS27080 | 53234..53485 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| CPZ03_RS27085 | 53585..54220 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| CPZ03_RS27090 | 54293..54580 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| CPZ03_RS27095 | 54593..54847 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| CPZ03_RS27100 | 54849..55490 | - | 642 | WP_001425343.1 | conjugal transfer protein TrbJ | - |
| CPZ03_RS27105 | 55496..56491 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| CPZ03_RS27110 | 56495..56752 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| CPZ03_RS27115 | 56749..57051 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| CPZ03_RS27120 | 57032..57289 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| CPZ03_RS27125 | 57322..57768 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| CPZ03_RS27690 | 57779..57949 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| CPZ03_RS27130 | 57953..58396 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61223 | 61223 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T31263 WP_000638823.1 NZ_AP017619:c53244-52963 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T31263 NZ_AP017619:c53244-52963 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT31263 WP_000121741.1 NZ_AP017619:c53485-53234 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT31263 NZ_AP017619:c53485-53234 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|