Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 7527..8028 Replicon plasmid pMRY15-117_2
Accession NZ_AP017619
Organism Escherichia coli strain MRY15-117

Toxin (Protein)


Gene name TsxA Uniprot ID H1ZXU8
Locus tag CPZ03_RS26810 Protein ID WP_000702247.1
Coordinates 7527..7787 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag CPZ03_RS26815 Protein ID WP_001132407.1
Coordinates 7777..8028 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ03_RS26760 3123..3284 + 162 WP_000775236.1 type I toxin-antitoxin system Hok family toxin -
CPZ03_RS26765 3434..4030 + 597 WP_000125165.1 hypothetical protein -
CPZ03_RS27755 4048..4332 - 285 WP_001162371.1 hypothetical protein -
CPZ03_RS26775 4406..5071 - 666 WP_000532148.1 P-loop NTPase -
CPZ03_RS26785 5669..5998 + 330 WP_000855120.1 hypothetical protein -
CPZ03_RS26795 6580..6903 + 324 WP_000427403.1 hypothetical protein -
CPZ03_RS26800 6945..7154 + 210 WP_000866036.1 hypothetical protein -
CPZ03_RS26805 7251..7475 + 225 WP_000814381.1 hypothetical protein -
CPZ03_RS26810 7527..7787 + 261 WP_000702247.1 hypothetical protein Toxin
CPZ03_RS26815 7777..8028 + 252 WP_001132407.1 transcriptional regulator Antitoxin
CPZ03_RS26830 8578..8856 + 279 WP_000545938.1 hypothetical protein -
CPZ03_RS26835 9276..9542 + 267 WP_000681608.1 type II toxin-antitoxin system HicB family antitoxin -
CPZ03_RS26840 9649..9831 - 183 WP_001481829.1 hypothetical protein -
CPZ03_RS26845 10389..10571 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
CPZ03_RS26850 10596..11033 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
CPZ03_RS26855 11164..11490 - 327 WP_063078684.1 hypothetical protein -
CPZ03_RS26860 11510..12217 - 708 WP_021503228.1 hypothetical protein -
CPZ03_RS26865 12219..12971 - 753 WP_000797966.1 conjugal transfer protein TraL -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 - 1..61223 61223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-37)


Sequences


Toxin        


Download         Length: 87 a.a.        Molecular weight: 9817.29 Da        Isoelectric Point: 10.0665

>T31262 WP_000702247.1 NZ_AP017619:7527-7787 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK

Download         Length: 261 bp

>T31262 NZ_AP017619:7527-7787 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.77 Da        Isoelectric Point: 9.8120

>AT31262 WP_001132407.1 NZ_AP017619:7777-8028 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp

>AT31262 NZ_AP017619:7777-8028 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1P8DNC0


Antitoxin

Source ID Structure

References