Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3356543..3357375 Replicon chromosome
Accession NZ_AP017617
Organism Escherichia coli strain MRY15-117

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag CPZ03_RS16865 Protein ID WP_000854753.1
Coordinates 3357001..3357375 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag CPZ03_RS16860 Protein ID WP_001540478.1
Coordinates 3356543..3356911 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ03_RS16825 3352375..3353055 + 681 WP_001282919.1 WYL domain-containing protein -
CPZ03_RS16830 3353203..3353880 + 678 WP_001097301.1 hypothetical protein -
CPZ03_RS16835 3353886..3354119 + 234 WP_001278283.1 DUF905 family protein -
CPZ03_RS16840 3354209..3355027 + 819 WP_001234382.1 DUF945 domain-containing protein -
CPZ03_RS16845 3355119..3355604 + 486 WP_023909076.1 antirestriction protein -
CPZ03_RS16850 3355620..3356096 + 477 WP_061092719.1 RadC family protein -
CPZ03_RS16855 3356159..3356380 + 222 WP_000692311.1 DUF987 domain-containing protein -
CPZ03_RS16860 3356543..3356911 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CPZ03_RS16865 3357001..3357375 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
CPZ03_RS16870 3357372..3357860 + 489 WP_000777545.1 hypothetical protein -
CPZ03_RS16875 3357872..3358069 + 198 WP_000839281.1 DUF957 domain-containing protein -
CPZ03_RS16880 3358166..3358735 + 570 WP_001290252.1 DUF4942 domain-containing protein -
CPZ03_RS16885 3359078..3359248 + 171 Protein_3141 IS110 family transposase -
CPZ03_RS16890 3360059..3361042 + 984 WP_001355482.1 KpsF/GutQ family sugar-phosphate isomerase -
CPZ03_RS16895 3361114..3362262 + 1149 WP_000905925.1 capsule polysaccharide transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sfaX / kpsF 3323118..3361042 37924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T31245 WP_000854753.1 NZ_AP017617:3357001-3357375 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T31245 NZ_AP017617:3357001-3357375 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT31245 WP_001540478.1 NZ_AP017617:3356543-3356911 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT31245 NZ_AP017617:3356543-3356911 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References