31243

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 3252347..3253682 Replicon chromosome
Accession NZ_AP017617
Organism Escherichia coli strain MRY15-117

Toxin (Protein)


Gene name sanaT Uniprot ID A0A0K4CDG2
Locus tag CPZ03_RS16265 Protein ID WP_001440173.1
Coordinates 3252735..3253682 (+) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A0K6A7X2
Locus tag CPZ03_RS16260 Protein ID WP_000208386.1
Coordinates 3252347..3252742 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ03_RS16210 3247833..3248318 + 486 WP_000213705.1 antirestriction protein -
CPZ03_RS16220 3248334..3248810 + 477 WP_001186715.1 RadC family protein -
CPZ03_RS16225 3248879..3249100 + 222 WP_000692345.1 DUF987 domain-containing protein -
CPZ03_RS16230 3249119..3249763 + 645 WP_000086770.1 hypothetical protein -
CPZ03_RS16235 3249813..3250181 + 369 WP_001285113.1 type IV toxin-antitoxin system YeeU family antitoxin -
CPZ03_RS16240 3250271..3250648 + 378 WP_000854719.1 TA system toxin CbtA family protein -
CPZ03_RS16245 3250645..3251133 + 489 WP_000761679.1 hypothetical protein -
CPZ03_RS16250 3251151..3251348 + 198 WP_000839266.1 DUF957 domain-containing protein -
CPZ03_RS16255 3251433..3252278 + 846 WP_001440175.1 DUF4942 domain-containing protein -
CPZ03_RS16260 3252347..3252742 + 396 WP_000208386.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
CPZ03_RS16265 3252735..3253682 + 948 WP_001440173.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CPZ03_RS16270 3254086..3255351 + 1266 WP_096427322.1 integrase arm-type DNA-binding domain-containing protein -
CPZ03_RS16275 3255673..3257172 - 1500 WP_096427323.1 phosphoethanolamine transferase -
CPZ03_RS16280 3257354..3258094 - 741 WP_001045031.1 porin family protein -
CPZ03_RS16285 3258204..3258680 - 477 WP_001275824.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-302)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 36284.66 Da        Isoelectric Point: 6.2532

>T31243 WP_001440173.1 NZ_AP017617:3252735-3253682 [Escherichia coli]
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRNRKRKIRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQTFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTELTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQHPQFRNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTN

Download         Length: 948 bp

>T31243 NZ_AP017617:3252735-3253682 [Escherichia coli]
ATGCCTGAATTAACATCATTATTTCCTGACGTTGCCAACGCACTGGATATTGAATCTGTCGCCATCGTCGAAAAAGATTA
TTTTGTGGTTAATCTTTTAAAGTTACTAAAAGAAATAAAACCAGAAACACATACTCTCGTGTTTGCAGGAGGTACCGCAT
TGTCAAAAGCTGGTATCTCATTGAACAGAATGTCAGAAGATATTGATATAAAGCTCGTGCCAACAGAGAACTTTATGCAA
AATGGCAGAAACAGGAAAAGAAAAATTCGCAAGGAAATCGTGCAAATAATCACGGATGTTCTTCATAATTCTGACATTTT
CAGCCTTGATAATGAAAACGCCCGTATAACACGTGATGAGTATCGTTATAACGAGATCCCCGTACGTTATCCCCAGACAT
TTGCCCAGGCCCCCTGTCTTCGTCCATTTATTAAGCTGGAGTTGATGGAAACCACTCTGCTGGAACACCCGGAAAGCAGA
GATATTTACTCACTCGTCACGGAGTTAACGGGTAATGGCACACCTGTAACAGCATTCCCCTGTGCCACCATTTTATCCAC
TCAGGCTGAAAAGCTCATATCCATGATGCGAAGAACAGCCATACTTCTTCGCAATCCCGAACAACAGGATGATGAGTCCC
TGGTACGCCACATTTACGACAATTATTGCATTGTCAGGGAAAAAGGTGTGAATGTTCCAGTACTGAAAAATTTTGTTCAG
ATATGTATTCAACAGGACATTGAGCGCTATGGTAACCAGCACCCACAATTTCGTAACTCACCAGTTGATGAACTTAAGAA
AGGGCTGGATGCACTCCGGGATGATCCTGTACACAAATTGCGTTTTCAACGATTTGTTAAACCGATGGTATTTGGTAATA
CACAGATTGACTGGGAAGAAGCCTACTCCTGTTTCAGACAAACAGCGTTGAGTGTTCTGACCAACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14639.00 Da        Isoelectric Point: 11.0607

>AT31243 WP_000208386.1 NZ_AP017617:3252347-3252742 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDRLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA

Download         Length: 396 bp

>AT31243 NZ_AP017617:3252347-3252742 [Escherichia coli]
ATGACTACAAAAGACCGTATTCAGTCCCGACTGAACCGTTCAAAGCGTTATGTGTTCACCCGGGATGACTTCAGGGATAT
CGCTGGCTATGATCAGGTTGGCAGAGCTCTTCGTACGCTGGTAAACGAAGGTAAGTTGATGAAAGTGGGCTATGGTGTTT
ACACCAAAGCCCGTCGCAACGTTATTACAGGAAAAATCATGCCTGCAGCACCTGGTGGCTCTGCCGCTGTAATCACCGAA
GCCCTGGATCGTTTGAATATCAGATACAGCTTGATCGGCGCAACAGAATGCTACAATAAAGGTCAGTCCACACAGATTCC
GGTATCTCCGGAGTTCAAAACACCTCCTCGCTTTAAAAGAGTGTTAGTTGTAGGGAAAAGTAAAATCAATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CDG2

Antitoxin

Source ID Structure
AlphaFold DB A0A0K6A7X2

References