Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1459939..1460612 Replicon chromosome
Accession NZ_AP017603
Organism Sphingopyxis sp. EG6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SPYCW_RS07220 Protein ID WP_120216229.1
Coordinates 1460190..1460612 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SPYCW_RS07215 Protein ID WP_120216228.1
Coordinates 1459939..1460193 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPYCW_RS07205 1457577..1458614 + 1038 WP_120216227.1 toprim domain-containing protein -
SPYCW_RS07210 1458926..1459852 + 927 WP_120218164.1 DUF2493 domain-containing protein -
SPYCW_RS07215 1459939..1460193 + 255 WP_120216228.1 plasmid stabilization protein Antitoxin
SPYCW_RS07220 1460190..1460612 + 423 WP_120216229.1 type II toxin-antitoxin system VapC family toxin Toxin
SPYCW_RS18955 1460896..1461063 + 168 WP_172595439.1 hypothetical protein -
SPYCW_RS07225 1461196..1461636 + 441 WP_120216230.1 hypothetical protein -
SPYCW_RS07230 1462208..1462534 + 327 WP_113480781.1 DUF736 domain-containing protein -
SPYCW_RS07235 1462825..1463085 + 261 WP_120216231.1 helix-turn-helix transcriptional regulator -
SPYCW_RS07240 1463188..1463451 + 264 WP_120216232.1 DUF2285 domain-containing protein -
SPYCW_RS07250 1463810..1464337 + 528 WP_197715663.1 DUF2285 domain-containing protein -
SPYCW_RS07255 1464583..1465563 - 981 WP_120216234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1416956..1483081 66125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15073.25 Da        Isoelectric Point: 4.5300

>T31184 WP_120216229.1 NZ_AP017603:1460190-1460612 [Sphingopyxis sp. EG6]
MILLDTNFVSEAMKPAPDDTVRVWLDEQAAETLYLSSVTIAELMFKIGALPDGKRKEKLADALDGVMELFADRVLPFDVG
AARHYAELAVKARAAGKGFPTPDGYIAAIAASKGFAVATRDTTAFDAAGVEVIDPWRAER

Download         Length: 423 bp

>T31184 NZ_AP017603:1460190-1460612 [Sphingopyxis sp. EG6]
ATGATCCTCCTCGACACCAACTTCGTGTCCGAGGCGATGAAGCCCGCACCCGACGATACCGTGCGCGTTTGGCTCGACGA
ACAGGCGGCGGAAACGCTCTATCTCTCCAGCGTCACGATCGCGGAGTTGATGTTCAAGATCGGTGCGCTTCCTGACGGCA
AGCGCAAGGAAAAGCTCGCCGACGCTCTGGACGGCGTGATGGAGCTGTTCGCGGATCGCGTCCTGCCGTTCGACGTCGGT
GCTGCTCGACATTATGCCGAGCTTGCCGTCAAAGCTCGCGCGGCTGGGAAGGGATTTCCTACACCCGACGGCTACATCGC
AGCGATCGCGGCCTCCAAGGGCTTTGCCGTCGCCACACGCGACACCACCGCATTCGATGCCGCCGGCGTTGAGGTCATCG
ACCCCTGGAGAGCAGAGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9305.59 Da        Isoelectric Point: 10.9144

>AT31184 WP_120216228.1 NZ_AP017603:1459939-1460193 [Sphingopyxis sp. EG6]
MPAVTIRNLPDATHRALKVRAAQHGRSAEAEMRDILETAVRPDTRLRLGSALAERSRRLGLTNEDVDALGQARDKTPTKP
MSFE

Download         Length: 255 bp

>AT31184 NZ_AP017603:1459939-1460193 [Sphingopyxis sp. EG6]
ATGCCCGCAGTCACGATCCGGAACCTGCCCGACGCGACGCACCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCGGAGGCCGAAATGCGCGACATCCTCGAGACGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCAGCGCTCTCGCGG
AACGTAGCCGCCGCCTCGGGCTGACCAATGAGGATGTCGATGCGCTCGGCCAAGCGCGCGACAAGACGCCGACCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References