Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 356649..357186 Replicon chromosome
Accession NZ_AP017603
Organism Sphingopyxis sp. EG6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag SPYCW_RS01665 Protein ID WP_172595398.1
Coordinates 356649..356951 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag SPYCW_RS01670 Protein ID WP_120215302.1
Coordinates 356944..357186 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPYCW_RS01635 351750..352865 + 1116 WP_120215295.1 alanine dehydrogenase -
SPYCW_RS01640 352888..353115 + 228 WP_120215296.1 hypothetical protein -
SPYCW_RS01645 353228..353659 - 432 WP_145985928.1 hypothetical protein -
SPYCW_RS01650 353937..354380 + 444 WP_120215298.1 succinate dehydrogenase, cytochrome b556 subunit -
SPYCW_RS01655 354380..354781 + 402 WP_120215299.1 succinate dehydrogenase, hydrophobic membrane anchor protein -
SPYCW_RS01660 354783..356597 + 1815 WP_120215300.1 succinate dehydrogenase flavoprotein subunit -
SPYCW_RS01665 356649..356951 - 303 WP_172595398.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPYCW_RS01670 356944..357186 - 243 WP_120215302.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SPYCW_RS01675 357219..357506 - 288 WP_120215303.1 hypothetical protein -
SPYCW_RS01680 357582..357785 - 204 WP_120215304.1 DUF167 domain-containing protein -
SPYCW_RS01685 357860..358855 - 996 WP_120218039.1 NADPH:quinone oxidoreductase family protein -
SPYCW_RS01690 358866..359459 - 594 WP_120215305.1 3-isopropylmalate dehydratase small subunit -
SPYCW_RS01695 359461..360312 - 852 WP_120215306.1 N-acyl homoserine lactonase family protein -
SPYCW_RS01700 360338..361768 - 1431 WP_120215307.1 3-isopropylmalate dehydratase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(5-73)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.10 Da        Isoelectric Point: 6.7277

>T31183 WP_172595398.1 NZ_AP017603:c356951-356649 [Sphingopyxis sp. EG6]
MLEIVLRPRAKADLLDIADYTIIEHGEKQAKQYIDDIRRQIGSAARFPGIGSGAFGLPQAYRKIRSGSHRVIYRYNETEL
IVVRILHQREDVPDEIEDFS

Download         Length: 303 bp

>T31183 NZ_AP017603:c356951-356649 [Sphingopyxis sp. EG6]
ATGCTTGAGATTGTGCTGCGGCCACGCGCCAAAGCCGACCTTTTGGATATCGCCGATTACACCATTATCGAACATGGCGA
GAAACAGGCGAAGCAATATATCGACGACATCCGCCGACAAATCGGGTCCGCCGCGCGATTTCCGGGGATCGGGAGTGGCG
CGTTCGGATTGCCCCAAGCTTATCGCAAGATCAGATCAGGGTCGCACCGGGTAATCTATCGCTACAATGAAACCGAACTT
ATCGTGGTCCGCATCCTCCACCAGCGCGAGGACGTCCCCGACGAGATTGAGGACTTTTCGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8856.91 Da        Isoelectric Point: 4.8011

>AT31183 WP_120215302.1 NZ_AP017603:c357186-356944 [Sphingopyxis sp. EG6]
MAIKNTSVALSDELADYARSKVASGEFGSVSDVVRDALRRAAERDLRIARLRQLVQEGEESGPARPFDWDAFMAEKFPNA

Download         Length: 243 bp

>AT31183 NZ_AP017603:c357186-356944 [Sphingopyxis sp. EG6]
ATGGCAATCAAGAACACCTCGGTCGCCTTGAGCGACGAACTGGCTGACTATGCGCGGAGCAAGGTTGCGTCGGGCGAGTT
CGGATCGGTCAGCGATGTCGTTCGCGATGCCTTGCGGCGTGCCGCCGAACGCGACCTGCGCATTGCGCGTCTCAGGCAGC
TCGTCCAGGAAGGCGAAGAAAGCGGCCCGGCGCGTCCGTTCGACTGGGATGCCTTTATGGCCGAAAAATTCCCGAATGCT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References