Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 126278..126785 Replicon chromosome
Accession NZ_AP017574
Organism Rickettsia japonica strain HH06154

Toxin (Protein)


Gene name relB Uniprot ID G4KM08
Locus tag BZI91_RS00760 Protein ID WP_014013837.1
Coordinates 126278..126541 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag BZI91_RS00765 Protein ID WP_014013838.1
Coordinates 126534..126785 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZI91_RS07655 121369..121491 + 123 WP_162557097.1 palindromic element RPE4 domain-containing protein -
BZI91_RS00735 121779..122165 + 387 Protein_136 hypothetical protein -
BZI91_RS00740 122244..122513 + 270 WP_096368100.1 hypothetical protein -
BZI91_RS08080 122535..122711 + 177 WP_158309285.1 hypothetical protein -
BZI91_RS00745 122815..124209 - 1395 WP_014120498.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
BZI91_RS00750 124206..124862 - 657 WP_014013835.1 lysophospholipid acyltransferase family protein -
BZI91_RS00755 125013..126218 - 1206 WP_014120499.1 pyridoxal phosphate-dependent aminotransferase -
BZI91_RS00760 126278..126541 - 264 WP_014013837.1 Txe/YoeB family addiction module toxin Toxin
BZI91_RS00765 126534..126785 - 252 WP_014013838.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BZI91_RS00770 126925..127929 + 1005 WP_014120500.1 methyltransferase domain-containing protein -
BZI91_RS00775 127934..128689 + 756 WP_024704441.1 VacJ family lipoprotein -
BZI91_RS00780 128709..129308 + 600 WP_014120502.1 phospholipid-binding protein MlaC -
BZI91_RS00790 129533..129820 + 288 WP_024704442.1 ribose-phosphate pyrophosphokinase-like domain-containing protein -
BZI91_RS08590 130007..130396 + 390 WP_197535037.1 palindromic element RPE1 domain-containing protein -
BZI91_RS00800 130541..131608 + 1068 WP_014120503.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10590.39 Da        Isoelectric Point: 9.8255

>T31165 WP_014013837.1 NZ_AP017574:c126541-126278 [Rickettsia japonica]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T31165 NZ_AP017574:c126541-126278 [Rickettsia japonica]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGTGTATTGGAAAAAATACGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCATCGTTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT31165 WP_014013838.1 NZ_AP017574:c126785-126534 [Rickettsia japonica]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT31165 NZ_AP017574:c126785-126534 [Rickettsia japonica]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCTGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGGGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3RG12

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3RZ38

References