Detailed information of TA system TA031159

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TacT2-vapB/DUF433(antitoxin)
• Location: 4467758..4468612
• Replicon: chromosome
• Accession: NZ_AP017560
• Organism: Pseudanabaena sp. ABRG5-3

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: ABRG53_RS20435
• Protein ID: WP_126389350.1
• Coordinates: 4467758..4468267 (+)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2Z5X3N1
• Locus tag: ABRG53_RS20440
• Protein ID: WP_055077550.1
• Coordinates: 4468382..4468612 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABRG53_RS20405	4463503..4464369	+	867	WP_126389338.1	alpha/beta hydrolase	-
ABRG53_RS20410	4464446..4464754	+	309	WP_126389340.1	hypothetical protein	-
ABRG53_RS20415	4465363..4466721	+	1359	WP_126389342.1	nicotinate phosphoribosyltransferase	-
ABRG53_RS20420	4466725..4467054	-	330	WP_126389344.1	type II toxin-antitoxin system PemK/MazF family toxin	-
ABRG53_RS20425	4467042..4467302	-	261	WP_126389346.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
ABRG53_RS20430	4467440..4467751	+	312	WP_126389348.1	DUF1778 domain-containing protein	-
ABRG53_RS20435	4467758..4468267	+	510	WP_126389350.1	GNAT family N-acetyltransferase	Toxin
ABRG53_RS20440	4468382..4468612	+	231	WP_055077550.1	DUF433 domain-containing protein	Antitoxin
ABRG53_RS20445	4468609..4468941	+	333	WP_126389352.1	DUF5615 family PIN-like protein	-
ABRG53_RS20450	4469014..4470474	+	1461	WP_126389354.1	hypothetical protein	-
ABRG53_RS20455	4470640..4471818	+	1179	WP_126389356.1	ATP-binding protein	-
ABRG53_RS20460	4471815..4472531	+	717	WP_126389358.1	hypothetical protein	-
ABRG53_RS20465	4472682..4472942	+	261	WP_126389360.1	hypothetical protein	-
ABRG53_RS20470	4472956..4473105	+	150	Protein_4065	nicotinic acid mononucleotide adenylyltransferase	-
ABRG53_RS20475	4473155..4473322	-	168	Protein_4066	DUF29 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4458365..4471818	13453

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (72-148)

Antitoxin

• Protein of unknown function DUF433 (7-62)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18667.75 Da
• Isoelectric Point: 8.6997

>T31159 WP_126389350.1 NZ_AP017560:4467758-4468267 [Pseudanabaena sp. ABRG5-3]
MSELEQVLNRPEKLNSSHQLDQFDCGNVQLNDWLKHRALKNELQGASRTYVVTVGKVVIAYYCLANGAIAQTISTGKVKR
NMPDPIPVMIIGRLAVDLNWQGKRIGKALLRDAILRTLQASEIAGIRAILVEAISEEAKQFYEKCGFTVSPLAPMTLMIT
INDAISSLT

Nucleotide

• Length: 510 bp

>T31159 NZ_AP017560:4467758-4468267 [Pseudanabaena sp. ABRG5-3]
ATGTCCGAATTGGAACAGGTGCTGAATCGACCAGAAAAACTTAATTCATCTCATCAACTCGATCAATTTGATTGTGGAAA
TGTTCAACTCAATGACTGGCTGAAACATCGGGCGCTCAAAAACGAATTGCAAGGTGCTTCGCGAACCTATGTTGTTACAG
TTGGGAAGGTAGTTATCGCCTATTATTGTCTAGCGAATGGTGCGATCGCGCAGACGATCTCCACAGGCAAAGTCAAGCGA
AATATGCCTGATCCTATTCCTGTGATGATTATTGGACGTTTGGCAGTTGATCTTAATTGGCAGGGCAAAAGAATTGGCAA
AGCGTTACTGAGAGATGCGATACTTCGCACTTTGCAGGCTTCTGAAATTGCGGGAATTAGAGCGATTTTAGTGGAAGCAA
TTTCTGAGGAGGCAAAGCAATTTTATGAGAAGTGTGGCTTTACGGTTTCGCCACTTGCGCCGATGACTTTGATGATTACC
ATCAACGATGCAATTTCATCTTTAACGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8605.95 Da
• Isoelectric Point: 5.6618

>AT31159 WP_055077550.1 NZ_AP017560:4468382-4468612 [Pseudanabaena sp. ABRG5-3]
MNYRNIITIEADKRGGKPCIRRMRITVYDVLGWLAAGMSHAEILDDFPELTEQDIRACLEFAADREHRLMAVVGAA

Nucleotide

• Length: 231 bp

>AT31159 NZ_AP017560:4468382-4468612 [Pseudanabaena sp. ABRG5-3]
ATGAACTACCGAAATATCATTACAATTGAAGCGGATAAACGAGGTGGTAAGCCTTGCATTCGCCGAATGCGTATTACTGT
ATATGATGTTTTGGGTTGGTTGGCGGCTGGAATGTCTCATGCTGAAATCTTAGATGATTTTCCAGAATTAACTGAGCAAG
ATATCAGGGCTTGTTTGGAGTTTGCTGCTGATCGGGAACATAGATTGATGGCTGTTGTGGGTGCTGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2Z5X3N1