Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT2-ataR/DUF1778(antitoxin)
Location 4467440..4468267 Replicon chromosome
Accession NZ_AP017560
Organism Pseudanabaena sp. ABRG5-3

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag ABRG53_RS20435 Protein ID WP_126389350.1
Coordinates 4467758..4468267 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag ABRG53_RS20430 Protein ID WP_126389348.1
Coordinates 4467440..4467751 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABRG53_RS20405 4463503..4464369 + 867 WP_126389338.1 alpha/beta hydrolase -
ABRG53_RS20410 4464446..4464754 + 309 WP_126389340.1 hypothetical protein -
ABRG53_RS20415 4465363..4466721 + 1359 WP_126389342.1 nicotinate phosphoribosyltransferase -
ABRG53_RS20420 4466725..4467054 - 330 WP_126389344.1 type II toxin-antitoxin system PemK/MazF family toxin -
ABRG53_RS20425 4467042..4467302 - 261 WP_126389346.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ABRG53_RS20430 4467440..4467751 + 312 WP_126389348.1 DUF1778 domain-containing protein Antitoxin
ABRG53_RS20435 4467758..4468267 + 510 WP_126389350.1 GNAT family N-acetyltransferase Toxin
ABRG53_RS20440 4468382..4468612 + 231 WP_055077550.1 DUF433 domain-containing protein -
ABRG53_RS20445 4468609..4468941 + 333 WP_126389352.1 DUF5615 family PIN-like protein -
ABRG53_RS20450 4469014..4470474 + 1461 WP_126389354.1 hypothetical protein -
ABRG53_RS20455 4470640..4471818 + 1179 WP_126389356.1 ATP-binding protein -
ABRG53_RS20460 4471815..4472531 + 717 WP_126389358.1 hypothetical protein -
ABRG53_RS20465 4472682..4472942 + 261 WP_126389360.1 hypothetical protein -
ABRG53_RS20470 4472956..4473105 + 150 Protein_4065 nicotinic acid mononucleotide adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4458365..4471818 13453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-148)

Antitoxin

Vibrio phage ICP1, Orf50

(23-97)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18667.75 Da        Isoelectric Point: 8.6997

>T31158 WP_126389350.1 NZ_AP017560:4467758-4468267 [Pseudanabaena sp. ABRG5-3]
MSELEQVLNRPEKLNSSHQLDQFDCGNVQLNDWLKHRALKNELQGASRTYVVTVGKVVIAYYCLANGAIAQTISTGKVKR
NMPDPIPVMIIGRLAVDLNWQGKRIGKALLRDAILRTLQASEIAGIRAILVEAISEEAKQFYEKCGFTVSPLAPMTLMIT
INDAISSLT

Download         Length: 510 bp

>T31158 NZ_AP017560:4467758-4468267 [Pseudanabaena sp. ABRG5-3]
ATGTCCGAATTGGAACAGGTGCTGAATCGACCAGAAAAACTTAATTCATCTCATCAACTCGATCAATTTGATTGTGGAAA
TGTTCAACTCAATGACTGGCTGAAACATCGGGCGCTCAAAAACGAATTGCAAGGTGCTTCGCGAACCTATGTTGTTACAG
TTGGGAAGGTAGTTATCGCCTATTATTGTCTAGCGAATGGTGCGATCGCGCAGACGATCTCCACAGGCAAAGTCAAGCGA
AATATGCCTGATCCTATTCCTGTGATGATTATTGGACGTTTGGCAGTTGATCTTAATTGGCAGGGCAAAAGAATTGGCAA
AGCGTTACTGAGAGATGCGATACTTCGCACTTTGCAGGCTTCTGAAATTGCGGGAATTAGAGCGATTTTAGTGGAAGCAA
TTTCTGAGGAGGCAAAGCAATTTTATGAGAAGTGTGGCTTTACGGTTTCGCCACTTGCGCCGATGACTTTGATGATTACC
ATCAACGATGCAATTTCATCTTTAACGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11921.47 Da        Isoelectric Point: 5.8309

>AT31158 WP_126389348.1 NZ_AP017560:4467440-4467751 [Pseudanabaena sp. ABRG5-3]
MSTPSQKTTDLTKPISKTRDLSINLRISQNQRDLIDRAATLQGKSRSEFMLDSAYQKAQDVLLDRCLFDVDEQRFQQFLD
RLDAPVMPNEHLRQLLTANAPWD

Download         Length: 312 bp

>AT31158 NZ_AP017560:4467440-4467751 [Pseudanabaena sp. ABRG5-3]
ATGTCTACGCCATCTCAAAAAACGACAGATCTGACTAAACCTATAAGTAAAACTCGTGACCTGTCGATTAATCTGCGGAT
TAGTCAAAACCAGCGAGACTTAATTGATCGCGCGGCAACATTACAAGGGAAAAGTCGCTCAGAGTTTATGCTAGATTCCG
CCTACCAGAAAGCACAGGATGTTCTACTCGATCGCTGTTTATTTGATGTCGATGAGCAGAGATTTCAACAATTCCTAGAC
CGTCTAGATGCGCCTGTGATGCCCAATGAACATCTGCGGCAGTTGCTCACTGCTAATGCTCCTTGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References