Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 4466725..4467302 Replicon chromosome
Accession NZ_AP017560
Organism Pseudanabaena sp. ABRG5-3

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ABRG53_RS20420 Protein ID WP_126389344.1
Coordinates 4466725..4467054 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ABRG53_RS20425 Protein ID WP_126389346.1
Coordinates 4467042..4467302 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABRG53_RS20395 4462113..4462331 + 219 WP_126389334.1 HypC/HybG/HupF family hydrogenase formation chaperone -
ABRG53_RS20400 4462342..4463433 + 1092 WP_126389336.1 hydrogenase formation protein HypD -
ABRG53_RS20405 4463503..4464369 + 867 WP_126389338.1 alpha/beta hydrolase -
ABRG53_RS20410 4464446..4464754 + 309 WP_126389340.1 hypothetical protein -
ABRG53_RS20415 4465363..4466721 + 1359 WP_126389342.1 nicotinate phosphoribosyltransferase -
ABRG53_RS20420 4466725..4467054 - 330 WP_126389344.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ABRG53_RS20425 4467042..4467302 - 261 WP_126389346.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABRG53_RS20430 4467440..4467751 + 312 WP_126389348.1 DUF1778 domain-containing protein -
ABRG53_RS20435 4467758..4468267 + 510 WP_126389350.1 GNAT family N-acetyltransferase -
ABRG53_RS20440 4468382..4468612 + 231 WP_055077550.1 DUF433 domain-containing protein -
ABRG53_RS20445 4468609..4468941 + 333 WP_126389352.1 DUF5615 family PIN-like protein -
ABRG53_RS20450 4469014..4470474 + 1461 WP_126389354.1 hypothetical protein -
ABRG53_RS20455 4470640..4471818 + 1179 WP_126389356.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4458365..4471818 13453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

SpoVT-AbrB domain

(11-52)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12396.49 Da        Isoelectric Point: 7.7893

>T31156 WP_126389344.1 NZ_AP017560:c4467054-4466725 [Pseudanabaena sp. ABRG5-3]
MGVVAKRFDVFLVNLDPTIGSEIQKTRPCVIVSPDEMNRYISTVIIAPMTTRGRIYPTRVICQFQGKDGQIVIDQIRTVD
KSRLVKKIGQISQEEQREVLDILAEMFAE

Download         Length: 330 bp

>T31156 NZ_AP017560:c4467054-4466725 [Pseudanabaena sp. ABRG5-3]
ATGGGAGTGGTAGCTAAGCGGTTTGATGTTTTTCTGGTTAATCTCGATCCTACGATCGGTAGCGAAATTCAAAAGACTCG
CCCCTGCGTGATTGTTTCACCAGATGAGATGAATCGCTATATTTCCACAGTGATTATTGCGCCAATGACAACTAGAGGCA
GAATCTATCCCACTCGCGTTATTTGTCAGTTTCAGGGTAAAGATGGACAAATAGTCATCGATCAAATTCGCACCGTCGAT
AAATCTCGATTGGTGAAAAAGATTGGTCAAATTAGCCAAGAGGAGCAAAGGGAAGTTCTTGATATTTTGGCGGAAATGTT
TGCGGAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9884.04 Da        Isoelectric Point: 4.0813

>AT31156 WP_126389346.1 NZ_AP017560:c4467302-4467042 [Pseudanabaena sp. ABRG5-3]
MSTAIRTRIIKIGNSQGIRIPKTLLEQSGIQTEVEISVDGDRLTIRPLQQLRTGWDQAFASMATQQDDVLLDEVNPTDWE
QDEWEW

Download         Length: 261 bp

>AT31156 NZ_AP017560:c4467302-4467042 [Pseudanabaena sp. ABRG5-3]
ATGAGTACAGCTATCAGAACTCGGATCATTAAAATTGGGAACTCTCAGGGCATCCGTATTCCCAAAACCTTGCTAGAACA
AAGCGGAATTCAAACAGAAGTTGAAATTAGTGTTGATGGCGATCGCTTGACTATTCGACCTCTCCAACAATTGCGGACTG
GTTGGGATCAAGCTTTCGCGTCAATGGCAACACAGCAAGATGATGTGCTTTTAGATGAAGTTAATCCAACAGATTGGGAG
CAGGATGAATGGGAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References