Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 128933..129519 Replicon chromosome
Accession NZ_AP017560
Organism Pseudanabaena sp. ABRG5-3

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag ABRG53_RS00590 Protein ID WP_126384263.1
Coordinates 128933..129268 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag ABRG53_RS00595 Protein ID WP_126384266.1
Coordinates 129265..129519 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABRG53_RS00555 124288..124696 - 409 Protein_112 HNH endonuclease -
ABRG53_RS00560 124693..125181 - 489 WP_126384249.1 hypothetical protein -
ABRG53_RS00565 125273..125515 + 243 WP_126384252.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ABRG53_RS00570 125509..125844 + 336 WP_126384254.1 endoribonuclease MazF -
ABRG53_RS00575 125995..127182 + 1188 WP_174235227.1 ATP-binding protein -
ABRG53_RS00580 127175..127702 + 528 WP_126384260.1 hypothetical protein -
ABRG53_RS00585 127763..128631 + 869 Protein_118 IS630 family transposase -
ABRG53_RS00590 128933..129268 - 336 WP_126384263.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ABRG53_RS00595 129265..129519 - 255 WP_126384266.1 antitoxin Antitoxin
ABRG53_RS00600 129675..129989 + 315 WP_126384269.1 hypothetical protein -
ABRG53_RS00605 130121..130717 + 597 WP_126384272.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
ABRG53_RS00610 131085..132464 + 1380 WP_126384275.1 phosphoglucosamine mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-108)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 11887.62 Da        Isoelectric Point: 9.1416

>T31149 WP_126384263.1 NZ_AP017560:c129268-128933 [Pseudanabaena sp. ABRG5-3]
VKRGDIYLVSLDPTEGHEQQGTRPVLIVSPDQFNALTKVPIVVPITSGGSFARTAGFAVSLDSAGTRTKGVVRCDQPRPI
DLSARKARKLESVPDTIVDDVLARIVTLFSS

Download         Length: 336 bp

>T31149 NZ_AP017560:c129268-128933 [Pseudanabaena sp. ABRG5-3]
GTGAAACGTGGTGATATATATCTTGTTTCGCTTGATCCAACGGAAGGTCATGAGCAACAGGGAACTAGACCAGTTTTGAT
TGTGTCTCCCGATCAATTCAATGCTTTAACCAAAGTTCCAATCGTGGTTCCAATTACATCAGGTGGAAGTTTTGCAAGAA
CCGCAGGTTTTGCTGTTTCTCTAGATTCTGCGGGAACTCGCACTAAAGGTGTAGTTCGTTGCGATCAACCTCGTCCTATT
GATTTATCTGCCCGTAAGGCTCGAAAGTTGGAGAGTGTGCCAGACACGATCGTTGATGATGTTTTGGCTAGGATTGTTAC
TCTATTTAGTTCCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9127.50 Da        Isoelectric Point: 4.2322

>AT31149 WP_126384266.1 NZ_AP017560:c129519-129265 [Pseudanabaena sp. ABRG5-3]
MHTTNLRKVGGSIMLAIPPAILEILNLQSGTTVGVAVDNGRLIIEPQPKPQYSLNELLAQCNPNAPITEDDRIWLDVEPV
GNEL

Download         Length: 255 bp

>AT31149 NZ_AP017560:c129519-129265 [Pseudanabaena sp. ABRG5-3]
ATGCACACCACAAATCTCCGTAAGGTCGGTGGCTCGATTATGTTGGCGATTCCTCCCGCCATTCTCGAAATTCTGAATCT
GCAATCAGGTACAACTGTGGGGGTTGCTGTTGACAATGGCAGATTGATTATTGAACCTCAACCGAAACCACAATATTCAC
TGAATGAGCTTTTGGCGCAGTGCAATCCGAATGCTCCGATAACGGAAGACGATCGCATTTGGCTAGATGTCGAGCCTGTG
GGGAATGAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References