Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 125273..125844 Replicon chromosome
Accession NZ_AP017560
Organism Pseudanabaena sp. ABRG5-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ABRG53_RS00570 Protein ID WP_126384254.1
Coordinates 125509..125844 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ABRG53_RS00565 Protein ID WP_126384252.1
Coordinates 125273..125515 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABRG53_RS00535 120759..121175 + 417 WP_126384237.1 bacteriohemerythrin -
ABRG53_RS00540 121289..122365 + 1077 WP_126384240.1 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase -
ABRG53_RS00545 122556..123662 + 1107 WP_126384243.1 iron-containing alcohol dehydrogenase family protein -
ABRG53_RS00550 123698..124138 - 441 WP_126384246.1 SufE family protein -
ABRG53_RS00555 124288..124696 - 409 Protein_112 HNH endonuclease -
ABRG53_RS00560 124693..125181 - 489 WP_126384249.1 hypothetical protein -
ABRG53_RS00565 125273..125515 + 243 WP_126384252.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABRG53_RS00570 125509..125844 + 336 WP_126384254.1 endoribonuclease MazF Toxin
ABRG53_RS00575 125995..127182 + 1188 WP_174235227.1 ATP-binding protein -
ABRG53_RS00580 127175..127702 + 528 WP_126384260.1 hypothetical protein -
ABRG53_RS00585 127763..128631 + 869 Protein_118 IS630 family transposase -
ABRG53_RS00590 128933..129268 - 336 WP_126384263.1 type II toxin-antitoxin system PemK/MazF family toxin -
ABRG53_RS00595 129265..129519 - 255 WP_126384266.1 antitoxin -
ABRG53_RS00600 129675..129989 + 315 WP_126384269.1 hypothetical protein -
ABRG53_RS00605 130121..130717 + 597 WP_126384272.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12520.52 Da        Isoelectric Point: 7.1650

>T31148 WP_126384254.1 NZ_AP017560:125509-125844 [Pseudanabaena sp. ABRG5-3]
MVKPYIPDRGDIVWLDFDPQAGHEQSGHRPAFVISPIAYNQRSNLALLCPITSKTKGWKFEVLLTDTKTKGVILADQIKS
LDWQARKIDFIEKASVSIINEVIDKIEALLT

Download         Length: 336 bp

>T31148 NZ_AP017560:125509-125844 [Pseudanabaena sp. ABRG5-3]
ATGGTAAAGCCATATATTCCCGATCGTGGTGATATTGTTTGGCTAGATTTTGATCCACAGGCTGGGCATGAACAATCTGG
GCATCGTCCTGCTTTTGTAATTTCGCCGATCGCCTATAATCAAAGATCAAACTTAGCTCTGCTTTGTCCGATTACTTCTA
AAACTAAGGGATGGAAGTTTGAGGTTCTACTCACGGATACTAAGACTAAGGGAGTGATTCTTGCTGATCAGATTAAGAGT
TTAGATTGGCAAGCGAGAAAGATAGATTTTATTGAGAAGGCTTCTGTAAGTATTATTAATGAAGTTATCGACAAGATTGA
AGCGTTATTAACATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8650.87 Da        Isoelectric Point: 5.5428

>AT31148 WP_126384252.1 NZ_AP017560:125273-125515 [Pseudanabaena sp. ABRG5-3]
MTAAIAKWGNSLAVRIPQAIAEQVQIQAGSEISIDIIDGKIVLTPHRRKKYTLDELLDGMASEHLHAEVSTGVSVGNEAW

Download         Length: 243 bp

>AT31148 NZ_AP017560:125273-125515 [Pseudanabaena sp. ABRG5-3]
ATGACTGCCGCGATCGCGAAGTGGGGTAATAGTCTAGCTGTACGCATTCCTCAAGCTATAGCTGAACAGGTGCAAATTCA
GGCTGGAAGCGAAATCAGTATTGATATTATTGATGGCAAGATTGTTTTGACTCCGCATCGGCGTAAGAAATACACTCTAG
ATGAATTACTGGATGGTATGGCTTCCGAGCATCTCCATGCAGAAGTTTCTACGGGTGTGTCTGTTGGGAATGAAGCATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References