Detailed information of TA system TA031146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2047564..2048083
• Replicon: chromosome
• Accession: NZ_AP017470
• Organism: Thermotomaculum hydrothermale strain AC55

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TTHT_RS09520
• Protein ID: WP_201327744.1
• Coordinates: 2047805..2048083 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: TTHT_RS09515
• Protein ID: WP_201327743.1
• Coordinates: 2047564..2047815 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TTHT_RS09490	2042994..2043968	+	975	WP_201327738.1	DGQHR domain-containing protein	-
TTHT_RS09495	2043965..2044981	-	1017	WP_201327739.1	hypothetical protein	-
TTHT_RS09500	2044914..2045978	-	1065	WP_201327740.1	hypothetical protein	-
TTHT_RS09505	2046000..2046854	-	855	WP_201327741.1	protein-glutamate O-methyltransferase CheR	-
TTHT_RS09510	2046945..2047487	+	543	WP_201327742.1	DUF4416 family protein	-
TTHT_RS09515	2047564..2047815	+	252	WP_201327743.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
TTHT_RS09520	2047805..2048083	+	279	WP_201327744.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TTHT_RS09525	2048139..2050148	+	2010	WP_201327745.1	NAD-dependent DNA ligase LigA	-
TTHT_RS09530	2050150..2050590	-	441	WP_201327746.1	DUF3592 domain-containing protein	-
TTHT_RS09535	2050599..2052062	-	1464	WP_201327747.1	hypothetical protein	-
TTHT_RS09540	2052285..2052749	-	465	WP_201327748.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11167.28 Da
• Isoelectric Point: 10.7611

>T31146 WP_201327744.1 NZ_AP017470:2047805-2048083 [Thermotomaculum hydrothermale]
MSYKLKFVKKALKEWEKLDGETREFFKKKLKSILKNPHNKRNKLKGFENVYKIKLKQKSYRLAYYVDDTEKSVTVLIIAH
RDDIYKKLGKRK

Nucleotide

• Length: 279 bp

>T31146 NZ_AP017470:2047805-2048083 [Thermotomaculum hydrothermale]
ATGAGCTATAAACTCAAATTTGTCAAAAAAGCCTTAAAGGAATGGGAAAAACTTGACGGTGAAACCAGAGAATTTTTCAA
AAAGAAGTTAAAATCAATCCTTAAAAACCCCCACAACAAGAGAAACAAACTGAAAGGCTTTGAAAATGTTTACAAAATTA
AATTAAAACAAAAAAGTTACCGCCTTGCTTACTATGTTGACGACACAGAAAAAAGCGTAACTGTTTTAATAATTGCCCAT
AGAGACGACATTTACAAAAAGCTTGGAAAAAGAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9578.20 Da
• Isoelectric Point: 6.9832

>AT31146 WP_201327743.1 NZ_AP017470:2047564-2047815 [Thermotomaculum hydrothermale]
MEKILSPFSVSISELKKSPKKIIENAKKTSVVVLNHNKPCAYILSPEQYENLLEKLEEKTFSEMVKERLKEKDKAVEISI
DEL

Nucleotide

• Length: 252 bp

>AT31146 NZ_AP017470:2047564-2047815 [Thermotomaculum hydrothermale]
ATGGAAAAGATACTTTCACCTTTCAGCGTAAGCATTAGCGAATTAAAAAAAAGCCCGAAAAAAATTATCGAAAATGCAAA
AAAAACTTCAGTGGTTGTATTAAACCACAATAAACCCTGTGCATACATTCTCTCCCCCGAACAATACGAAAACCTTTTGG
AAAAATTAGAGGAAAAAACATTTTCGGAAATGGTAAAGGAAAGACTAAAAGAAAAAGATAAAGCTGTTGAAATAAGTATT
GATGAGCTATAA