Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3277824..3278415 Replicon chromosome
Accession NZ_AP017469
Organism Hafnia sp. CBA7124

Toxin (Protein)


Gene name Hha Uniprot ID A0A097R540
Locus tag CPY98_RS15075 Protein ID WP_025799954.1
Coordinates 3278212..3278415 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A097R537
Locus tag CPY98_RS15070 Protein ID WP_025799952.1
Coordinates 3277824..3278192 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPY98_RS15045 3272945..3273397 + 453 WP_043494953.1 NfeD family protein -
CPY98_RS15050 3273442..3273849 - 408 WP_043494954.1 Cu(I)-responsive transcriptional regulator -
CPY98_RS15055 3273972..3276731 + 2760 WP_096388286.1 copper-exporting P-type ATPase CopA -
CPY98_RS15060 3276898..3277170 + 273 WP_043494989.1 type B 50S ribosomal protein L31 -
CPY98_RS15065 3277170..3277310 + 141 WP_004091741.1 type B 50S ribosomal protein L36 -
CPY98_RS15070 3277824..3278192 + 369 WP_025799952.1 Hha toxicity modulator TomB Antitoxin
CPY98_RS15075 3278212..3278415 + 204 WP_025799954.1 hemolysin expression modulator Hha Toxin
CPY98_RS15080 3278615..3279034 - 420 WP_043495008.1 DUF1311 domain-containing protein -
CPY98_RS15090 3279521..3279859 + 339 WP_043494994.1 MGMT family protein -
CPY98_RS15095 3279907..3280425 - 519 WP_025799960.1 YbaY family lipoprotein -
CPY98_RS15100 3280718..3281578 + 861 WP_096388288.1 acyl-CoA thioesterase II -
CPY98_RS15105 3281660..3282952 - 1293 WP_172625153.1 ammonium transporter AmtB -
CPY98_RS15110 3282983..3283321 - 339 WP_004091732.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.40 Da        Isoelectric Point: 5.8423

>T31143 WP_025799954.1 NZ_AP017469:3278212-3278415 [Hafnia sp. CBA7124]
MTKIDYLMRLRKCTTLETLERVIEKNKYELSDDELETFYSAADHRLAELTMNKLYDKIPAEVWKYVR

Download         Length: 204 bp

>T31143 NZ_AP017469:3278212-3278415 [Hafnia sp. CBA7124]
ATGACTAAAATTGATTACCTTATGCGCTTACGAAAGTGTACAACGTTAGAAACTTTAGAGCGCGTAATTGAAAAAAACAA
ATATGAGCTATCCGACGATGAGCTAGAAACTTTCTACTCAGCCGCCGACCATCGTTTGGCCGAACTCACCATGAACAAAC
TGTATGATAAGATCCCTGCTGAAGTTTGGAAGTATGTTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14201.03 Da        Isoelectric Point: 4.7386

>AT31143 WP_025799952.1 NZ_AP017469:3277824-3278192 [Hafnia sp. CBA7124]
MDEYTSYQHDITELKYLCNMLYNQGMEVLSDSHHGWVNDPTAVANLQLNELNEHIATFGLTFKIKYPKSSELTEILDEYL
DETYSLFSNYSINEPELKKWLKVKGRILRYLAGEKPASALNF

Download         Length: 369 bp

>AT31143 NZ_AP017469:3277824-3278192 [Hafnia sp. CBA7124]
ATGGATGAGTACACGTCTTATCAGCACGATATAACTGAACTGAAATACCTGTGTAATATGCTGTATAATCAGGGAATGGA
AGTTCTGAGTGATAGCCATCATGGCTGGGTTAATGACCCAACTGCTGTAGCTAATCTGCAACTCAATGAATTAAACGAAC
ATATCGCAACGTTCGGTTTAACGTTCAAGATTAAGTATCCAAAGAGTTCAGAATTAACTGAAATATTAGATGAGTATCTT
GACGAAACTTACAGTCTGTTTAGTAATTACAGCATAAACGAACCAGAACTAAAAAAATGGCTTAAAGTAAAAGGCCGTAT
TTTGCGTTATTTAGCGGGTGAAAAACCAGCATCCGCGTTGAACTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097R540

Antitoxin

Source ID Structure
AlphaFold DB A0A097R537

References