Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 750076..750736 Replicon chromosome
Accession NZ_AP017469
Organism Hafnia sp. CBA7124

Toxin (Protein)


Gene name cptA Uniprot ID A0A377PEM3
Locus tag CPY98_RS03545 Protein ID WP_043490966.1
Coordinates 750323..750736 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A097QZ09
Locus tag CPY98_RS03540 Protein ID WP_025801623.1
Coordinates 750076..750342 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPY98_RS03520 745344..745994 - 651 WP_025801627.1 hemolysin III family protein -
CPY98_RS03525 746655..747539 + 885 WP_043490960.1 nucleoside-specific channel-forming protein Tsx -
CPY98_RS03530 747741..748559 + 819 WP_096386374.1 shikimate 5-dehydrogenase -
CPY98_RS03535 748708..749697 - 990 WP_043490963.1 tRNA-modifying protein YgfZ -
CPY98_RS03540 750076..750342 + 267 WP_025801623.1 FAD assembly factor SdhE Antitoxin
CPY98_RS03545 750323..750736 + 414 WP_043490966.1 protein YgfX Toxin
CPY98_RS03550 750823..751341 - 519 WP_040046181.1 flavodoxin FldB -
CPY98_RS03555 751546..752445 + 900 WP_043491009.1 site-specific tyrosine recombinase XerD -
CPY98_RS03560 752473..753189 + 717 WP_025801619.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CPY98_RS03565 753195..754928 + 1734 WP_043490968.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16198.93 Da        Isoelectric Point: 8.1501

>T31133 WP_043490966.1 NZ_AP017469:750323-750736 [Hafnia sp. CBA7124]
VDQWRCDVRVSWRTQLLLLVTHGILILLILLAPWPENYSFYWLVLLTLVVFECIRSQKQIAKIQGEFSFLADNHIQWQQN
EWELCKTPWISDFGALLPLRSVKPQGTKKRLWIAADSLTPEAWCHLRRTLMQTHQSD

Download         Length: 414 bp

>T31133 NZ_AP017469:750323-750736 [Hafnia sp. CBA7124]
GTGGACCAATGGCGTTGTGATGTACGAGTGTCATGGCGAACGCAACTCTTGTTGTTAGTTACGCATGGCATTCTGATTTT
GTTGATTTTGCTAGCACCCTGGCCGGAAAACTATAGTTTTTATTGGTTGGTGTTGCTGACTTTAGTTGTGTTTGAATGTA
TCCGCAGCCAAAAGCAGATCGCTAAGATTCAGGGAGAGTTTAGCTTTCTAGCTGATAACCATATTCAATGGCAACAGAAC
GAATGGGAGTTATGTAAGACGCCTTGGATCAGTGATTTTGGCGCATTGCTACCCTTGAGAAGTGTGAAGCCGCAGGGAAC
GAAAAAGCGTTTATGGATTGCGGCAGACAGTTTGACGCCAGAGGCGTGGTGCCATTTGCGCCGCACTTTGATGCAAACCC
ACCAGAGTGATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10345.85 Da        Isoelectric Point: 6.0684

>AT31133 WP_025801623.1 NZ_AP017469:750076-750342 [Hafnia sp. CBA7124]
MDIGNKSRIHWACRRGMRELDISIMPFFEHEYDSLSDADKQTFVRLLECDDPDLFNWLMNHGSPKDPELAHMVKLIQTRN
KDRGPMAL

Download         Length: 267 bp

>AT31133 NZ_AP017469:750076-750342 [Hafnia sp. CBA7124]
ATGGATATAGGAAATAAATCACGCATTCATTGGGCCTGTCGCCGCGGTATGCGTGAGCTGGATATCTCCATTATGCCGTT
TTTCGAACATGAGTATGATTCACTGAGCGATGCAGACAAACAGACATTTGTACGCTTACTTGAGTGCGACGATCCCGATC
TTTTTAATTGGCTCATGAACCACGGTTCACCCAAGGATCCTGAATTAGCGCATATGGTTAAACTTATTCAAACGCGAAAC
AAAGATCGTGGACCAATGGCGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377PEM3

Antitoxin

Source ID Structure
AlphaFold DB A0A097QZ09

References