Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4401391..4402015 Replicon chromosome
Accession NZ_AP017423
Organism Pseudomonas sp. LAB-08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LAB08_RS19910 Protein ID WP_096513026.1
Coordinates 4401391..4401570 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LAB08_RS19915 Protein ID WP_096515535.1
Coordinates 4401608..4402015 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAB08_RS19880 4396440..4397933 + 1494 WP_096513021.1 sensor domain-containing diguanylate cyclase -
LAB08_RS19885 4397920..4398138 + 219 WP_096513022.1 cysteine-rich CWC family protein -
LAB08_RS19890 4398173..4398865 + 693 WP_096513023.1 pseudouridine synthase -
LAB08_RS19895 4399179..4400063 + 885 WP_096513024.1 alpha/beta hydrolase -
LAB08_RS19905 4400607..4401062 - 456 WP_096513025.1 EcsC family protein -
LAB08_RS19910 4401391..4401570 + 180 WP_096513026.1 type II toxin-antitoxin system HicA family toxin Toxin
LAB08_RS19915 4401608..4402015 + 408 WP_096515535.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LAB08_RS19920 4402185..4403360 - 1176 WP_096513027.1 acyltransferase -
LAB08_RS19925 4403872..4404642 - 771 WP_096513028.1 trans-aconitate 2-methyltransferase -
LAB08_RS19930 4404777..4405187 + 411 WP_096513029.1 low affinity iron permease family protein -
LAB08_RS19935 4405233..4405736 - 504 WP_096513030.1 DUF4142 domain-containing protein -
LAB08_RS19940 4405809..4405964 - 156 WP_096513031.1 stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6670.95 Da        Isoelectric Point: 11.4113

>T31127 WP_096513026.1 NZ_AP017423:4401391-4401570 [Pseudomonas izuensis]
VNSRLLISQLVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Download         Length: 180 bp

>T31127 NZ_AP017423:4401391-4401570 [Pseudomonas izuensis]
GTGAATAGCCGACTTTTGATAAGCCAACTCGTTGCGGACGGCTGGTATCTGGTACGAATCAGAGGCAGCCACCATCACTT
CAAGCATCCGACCAAACCGGGGCTGGTGACGGTTCCTCATCCCAAAAAAGATCTGCTCAAAAAAACGGCCATCAGTATTT
TGCAACAGGCGCTGCTGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14734.74 Da        Isoelectric Point: 4.4077

>AT31127 WP_096515535.1 NZ_AP017423:4401608-4402015 [Pseudomonas izuensis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDDSPIPPASKVTLHAANPKYTGCAWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQN

Download         Length: 408 bp

>AT31127 NZ_AP017423:4401608-4402015 [Pseudomonas izuensis]
ATGCTTTACCCAATTGCGATTTCAATGGGCGATGACGAACATGCCTGGGGTGTGGAAGTGCCCGACATTCCGGGGTGCTT
TTCCGCCGGGGAAGATCTGGATGACGCGATGGCGATGGCCCGGGAAGCCATTGAAGGCCACTTCGAAATTCTGGCCGAAG
ATGATTCGCCAATCCCGCCCGCAAGCAAAGTGACCCTGCATGCAGCCAACCCGAAGTACACGGGCTGTGCGTGGGCATTG
GTGGACATCGACGTTACCAAATATCTGGGTAAGGCCCAGAAGCTGAACATCACGCTGCCAGGCTACCTGCTCAACCGGAT
TGATGAATACGTGCTGCACCACCCTGAGGAAAAAAGCCGTTCGGGTTTTCTGGCATCGGCAGCACTGAAGGTATTACAGC
AGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References