Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 667351..667967 Replicon chromosome
Accession NZ_AP017423
Organism Pseudomonas sp. LAB-08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LAB08_RS03210 Protein ID WP_096515234.1
Coordinates 667351..667563 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LAB08_RS03215 Protein ID WP_096509610.1
Coordinates 667563..667967 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAB08_RS03185 663148..663954 + 807 WP_096509605.1 phosphonate C-P lyase system protein PhnK -
LAB08_RS03190 663954..664673 + 720 WP_096509606.1 phosphonate C-P lyase system protein PhnL -
LAB08_RS03195 664663..665808 + 1146 WP_096509607.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
LAB08_RS03200 665808..666374 + 567 WP_096509608.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
LAB08_RS03205 666365..667114 + 750 WP_096509609.1 phosphonate metabolism protein PhnP -
LAB08_RS03210 667351..667563 + 213 WP_096515234.1 type II toxin-antitoxin system HicA family toxin Toxin
LAB08_RS03215 667563..667967 + 405 WP_096509610.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LAB08_RS03220 668066..669271 - 1206 WP_096509611.1 MFS transporter -
LAB08_RS03225 669507..670136 + 630 WP_096509612.1 hypothetical protein -
LAB08_RS03230 670243..670686 + 444 WP_096509613.1 hypothetical protein -
LAB08_RS03235 670854..671849 - 996 WP_096509614.1 sulfate ABC transporter substrate-binding protein -
LAB08_RS03240 672077..672901 - 825 WP_096509615.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7986.30 Da        Isoelectric Point: 10.6275

>T31125 WP_096515234.1 NZ_AP017423:667351-667563 [Pseudomonas izuensis]
VQSRLLIKEMMEAGWTLDRITGSHHIFTHRYNPYTIPVPHPKKDLPVGTVKSIRRRAGLFFPLASYAGDP

Download         Length: 213 bp

>T31125 NZ_AP017423:667351-667563 [Pseudomonas izuensis]
GTGCAAAGCAGGCTATTGATCAAGGAGATGATGGAAGCAGGTTGGACGTTGGACCGAATCACTGGCAGTCATCACATCTT
CACTCACCGCTACAACCCATACACGATTCCCGTTCCTCACCCGAAAAAGGATTTGCCGGTGGGGACGGTCAAGAGCATCA
GGAGGCGAGCCGGGCTTTTTTTCCCGCTGGCCAGTTACGCAGGAGATCCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14931.08 Da        Isoelectric Point: 4.2149

>AT31125 WP_096509610.1 NZ_AP017423:667563-667967 [Pseudomonas izuensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEIAASGEPIPMPTSMVEHLANPDFIEMGWGM
LEIDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT31125 NZ_AP017423:667563-667967 [Pseudomonas izuensis]
ATGCAATATCCAATCTGTATCGAGTGGGGCGATGAGAACACCGCCATCGGTATTCAGATCCCCGATATTCCAGGTGCGGT
AACCGCCGGGGATACCTTTGAAGATGCCTATAACGCGGCGGTCGAGATTGCCCACATCATGCTGCAAGAGATCGCGGCGA
GTGGAGAGCCGATTCCGATGCCGACGTCCATGGTTGAACATCTCGCAAATCCCGATTTCATCGAGATGGGCTGGGGCATG
CTGGAAATCGACATTTCGCCCTATATGGGCAAGACCGAGAAGGTCAACGTGACGCTGCCGGGCTATGTGATCCAGCGAAT
CGACCGTTATGTGCGCGAACACAACGTCAAAAGTCGCTCGTCGTTCCTGGCGGATGCGGCGATGGAGAAGCTGGTTCGGT
ATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References