Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsaAT/-
Location 860823..861300 Replicon chromosome
Accession NZ_AP017377
Organism Staphylococcus aureus strain OC8

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag ATE38_RS04300 Protein ID WP_000052078.1
Coordinates 860823..861011 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ATE38_RS04305 Protein ID WP_001059690.1
Coordinates 861040..861300 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE38_RS04270 856864..857334 + 471 WP_000824472.1 hypothetical protein -
ATE38_RS04275 857675..858361 + 687 WP_001548082.1 thermonuclease family protein -
ATE38_RS04280 858718..858918 + 201 WP_001059082.1 cold-shock protein -
ATE38_RS04285 859414..859632 - 219 WP_000005886.1 hypothetical protein -
ATE38_RS04290 859694..859978 - 285 WP_001004395.1 hypothetical protein -
ATE38_RS04295 860066..860635 - 570 WP_001106654.1 hypothetical protein -
ATE38_RS04300 860823..861011 - 189 WP_000052078.1 hypothetical protein Toxin
ATE38_RS04305 861040..861300 - 261 WP_001059690.1 hypothetical protein Antitoxin
ATE38_RS04310 861641..861844 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ATE38_RS04315 861841..862077 - 237 WP_000368687.1 hypothetical protein -
ATE38_RS04320 862302..862883 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
ATE38_RS04325 862956..863573 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
ATE38_RS04330 863728..864222 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
ATE38_RS04335 864621..865043 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
ATE38_RS04340 865191..865907 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin

(88-134)


Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T31105 WP_000052078.1 NZ_AP017377:c861011-860823 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T31105 NZ_AP017377:c861011-860823 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT31105 WP_001059690.1 NZ_AP017377:c861300-861040 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT31105 NZ_AP017377:c861300-861040 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References