Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 93827..94445 Replicon plasmid plasmid1 DNA
Accession NZ_AP017376
Organism Stanieria sp. NIES-3757

Toxin (Protein)


Gene name mazF Uniprot ID K9XZS7
Locus tag STA3757_RS24350 Protein ID WP_015211942.1
Coordinates 94098..94445 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID K9Y216
Locus tag STA3757_RS24345 Protein ID WP_015211941.1
Coordinates 93827..94093 (+) Length 89 a.a.

Genomic Context

STA3757_RS24335STA3757_RS24340STA3757_RS24345STA3757_RS24350STA3757_RS24360STA3757_RS24355STA3757_RS24365STA3757_RS24370STA3757_RS24375STA3757_RS24380
Location: 90537..91469 (933 bp)
Type: Others
Protein ID: WP_096388342.1
Location: 91808..93733 (1926 bp)
Type: Others
Protein ID: WP_096388344.1
Location: 93827..94093 (267 bp)
Type: Antitoxin
Protein ID: WP_015211941.1
Location: 94098..94445 (348 bp)
Type: Toxin
Protein ID: WP_015211942.1
Location: 95528..95809 (282 bp)
Type: Others
Protein ID: WP_015211944.1
Location: 94472..95452 (981 bp)
Type: Others
Protein ID: WP_096388346.1
Location: 96037..96693 (657 bp)
Type: Others
Protein ID: WP_096388348.1
Location: 96783..97124 (342 bp)
Type: Others
Protein ID: WP_096388429.1
Location: 97165..98913 (1749 bp)
Type: Others
Protein ID: WP_096388350.1
Location: 99043..99399 (357 bp)
Type: Others
Protein ID: WP_096388352.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
STA3757_RS2433590537..91469+933WP_096388342.1hypothetical protein-
STA3757_RS2434091808..93733+1926WP_096388344.1DNA-directed DNA polymerase-
STA3757_RS2434593827..94093+267WP_015211941.1CopG family proteinAntitoxin
STA3757_RS2435094098..94445+348WP_015211942.1type II toxin-antitoxin system PemK/MazF family toxinToxin
STA3757_RS2435594472..95452-981WP_096388346.1hypothetical protein-
STA3757_RS2436095528..95809+282WP_015211944.1hypothetical protein-
STA3757_RS2436596037..96693-657WP_096388348.1hypothetical protein-
STA3757_RS2437096783..97124-342WP_096388429.1hypothetical protein-
STA3757_RS2437597165..98913-1749WP_096388350.1VWA domain-containing protein-
STA3757_RS2438099043..99399-357WP_096388352.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..143540143540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13178.45 Da        Isoelectric Point: 10.6786

>T31104 WP_015211942.1 NZ_AP017376:94098-94445 [Stanieria sp. NIES-3757]
MSSPVYRQLEIRWIDLEPTRGAETQKKRPCVIIQADIVNQGSKTIIIAPILPGHKNWPFAVNVKPSKSNGLDKERHINLK
QMRAVDVSRIQNRQGILEQQYLKPLQEAIKIIFAL

Download         Length: 348 bp

>T31104 NZ_AP017376:94098-94445 [Stanieria sp. NIES-3757]
ATGAGTTCTCCTGTTTATCGGCAATTGGAAATAAGATGGATCGATCTCGAGCCGACAAGGGGTGCTGAAACTCAAAAAAA
AAGACCATGCGTTATTATCCAAGCCGACATTGTTAACCAGGGGTCGAAGACAATTATTATTGCTCCTATTCTTCCAGGAC
ATAAAAATTGGCCTTTTGCAGTCAATGTCAAACCTAGCAAGAGTAACGGATTAGATAAAGAACGACATATCAACCTCAAG
CAGATGAGAGCAGTTGATGTTTCCCGCATCCAAAATCGCCAAGGAATTCTGGAACAGCAATATTTGAAACCGCTTCAGGA
AGCTATTAAGATAATTTTCGCGCTCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9891.02 Da        Isoelectric Point: 4.2577

>AT31104 WP_015211941.1 NZ_AP017376:93827-94093 [Stanieria sp. NIES-3757]
MTHRATITLDDDAYAFLEASAGNNRSAYINKLLKEEKQRVLAKQIMRANQEEASDLAYQEELMNWDVTLSDGLNERDTAV
SAACPIEL

Download         Length: 267 bp

>AT31104 NZ_AP017376:93827-94093 [Stanieria sp. NIES-3757]
ATGACCCATCGTGCAACTATTACTCTAGATGATGATGCCTACGCCTTTTTAGAAGCTTCAGCGGGGAATAATCGTAGTGC
TTATATCAATAAGCTGCTTAAAGAAGAAAAACAACGAGTATTGGCAAAACAGATAATGAGAGCCAATCAAGAAGAAGCTT
CTGACCTTGCTTATCAAGAAGAGCTAATGAATTGGGATGTAACATTGTCTGATGGATTGAACGAGAGGGACACTGCGGTT
TCCGCAGCTTGTCCAATCGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBK9XZS7

Antitoxin

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Source
ID
Structure
AlphaFold DBK9Y216

References