Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-parD/HigB-RHH
Location 1235645..1236283 Replicon chromosome
Accession NZ_AP017369
Organism Corynebacterium suranareeae strain N24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N24_RS05875 Protein ID WP_096455167.1
Coordinates 1236002..1236283 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag N24_RS05870 Protein ID WP_096455165.1
Coordinates 1235645..1235878 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N24_RS05850 1232182..1233267 + 1086 WP_096459814.1 redox-regulated ATPase YchF -
N24_RS05855 1233300..1234118 + 819 WP_096455159.1 ornithine carbamoyltransferase -
N24_RS05860 1234280..1234672 + 393 WP_197702426.1 hypothetical protein -
N24_RS05865 1234730..1235134 - 405 WP_096455163.1 hypothetical protein -
N24_RS16240 1235353..1235529 + 177 WP_157736405.1 hypothetical protein -
N24_RS05870 1235645..1235878 + 234 WP_096455165.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
N24_RS05875 1236002..1236283 + 282 WP_096455167.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N24_RS05880 1236258..1236578 + 321 WP_096455169.1 HigA family addiction module antidote protein -
N24_RS05885 1236712..1237530 + 819 WP_197702379.1 siderophore-interacting protein -
N24_RS05890 1237808..1238191 + 384 WP_096459822.1 MmcQ/YjbR family DNA-binding protein -
N24_RS05895 1238282..1239100 + 819 WP_096455171.1 DUF108 domain-containing protein -
N24_RS05900 1239160..1239600 + 441 WP_096455173.1 YtoQ family protein -
N24_RS05905 1239611..1240018 - 408 WP_157736406.1 VOC family protein -
N24_RS05910 1240167..1240622 + 456 WP_096459825.1 NUDIX domain-containing protein -
N24_RS05915 1240822..1241190 - 369 WP_096455175.1 SMI1/KNR4 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11007.47 Da        Isoelectric Point: 9.9953

>T31092 WP_096455167.1 NZ_AP017369:1236002-1236283 [Corynebacterium suranareeae]
VIRTFGDKNTERIWHEYYVKGIDRKVQRATLRKLEQIHAAQNVEDLRIPPGNRLERLVGDRRGQHSVRVNAQWRICFVWK
DGGADNVELVDYH

Download         Length: 282 bp

>T31092 NZ_AP017369:1236002-1236283 [Corynebacterium suranareeae]
GTGATCAGAACCTTCGGCGATAAGAATACTGAGCGGATCTGGCACGAGTATTACGTCAAAGGTATTGATCGCAAAGTTCA
ACGGGCAACATTGCGAAAGCTTGAGCAGATTCATGCGGCGCAAAATGTCGAAGACCTCAGAATTCCACCTGGGAATCGAT
TGGAGCGATTAGTCGGTGATCGCCGTGGTCAACATAGTGTTCGTGTGAATGCGCAATGGCGGATTTGTTTTGTTTGGAAA
GATGGAGGTGCGGACAATGTCGAACTCGTCGACTATCACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8486.43 Da        Isoelectric Point: 4.3988

>AT31092 WP_096455165.1 NZ_AP017369:1235645-1235878 [Corynebacterium suranareeae]
MAINISISLDNHFAAFLAEQVALGRYRTESNVVRASLQLLERRETHIAALRDALVDGEASGEAEEFDFDSFIASKTS

Download         Length: 234 bp

>AT31092 NZ_AP017369:1235645-1235878 [Corynebacterium suranareeae]
ATGGCTATAAATATCTCAATCAGCCTTGATAATCATTTCGCAGCGTTCCTTGCTGAACAGGTCGCCTTAGGTCGATATCG
AACTGAAAGTAACGTTGTTCGCGCCAGTTTACAGTTGTTAGAGCGACGAGAGACCCACATTGCTGCCTTGCGTGACGCGT
TGGTCGATGGTGAGGCTAGTGGGGAAGCAGAAGAATTTGATTTTGATTCCTTCATTGCTTCAAAGACCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References