Detailed information of TA system TA031090

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 2188237..2188799
• Replicon: chromosome
• Accession: NZ_AP017367
• Organism: Leptolyngbya sp. O-77

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: O77CONTIG1_RS09305
• Protein ID: WP_068510006.1
• Coordinates: 2188458..2188799 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: O77CONTIG1_RS23450
• Protein ID: WP_084782999.1
• Coordinates: 2188237..2188461 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O77CONTIG1_RS24425	2184671..2185855	+	1185	WP_156435111.1	ATP-binding protein	-
O77CONTIG1_RS09295	2185839..2187155	+	1317	WP_156435113.1	hypothetical protein	-
O77CONTIG1_RS09300	2187148..2188209	+	1062	WP_156435116.1	hypothetical protein	-
O77CONTIG1_RS23450	2188237..2188461	+	225	WP_084782999.1	DUF433 domain-containing protein	Antitoxin
O77CONTIG1_RS09305	2188458..2188799	+	342	WP_068510006.1	DUF5615 family PIN-like protein	Toxin
O77CONTIG1_RS24430	2188895..2189176	-	282	WP_156435118.1	hypothetical protein	-
O77CONTIG1_RS24435	2189327..2189515	-	189	WP_156435119.1	hypothetical protein	-
O77CONTIG1_RS09310	2189765..2192665	+	2901	WP_084782446.1	isoleucine--tRNA ligase	-
O77CONTIG1_RS23455	2192966..2193256	+	291	WP_084783000.1	YlxR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2177892..2188799	10907

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (4-79)

Antitoxin

• Protein of unknown function DUF433 (8-63)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12413.20 Da
• Isoelectric Point: 4.1207

>T31090 WP_068510006.1 NZ_AP017367:2188458-2188799 [Leptolyngbya sp. O-77]
MTTIWIDAHLSPAIATWITDTFGITALALRDLGLRDAEDPEIFEAAKAQGVIFMTKDSDFVDLVERLGSPPQIIWLTCGN
TSNARLREILSSVLPETLELLRSGEKLVEISGD

Nucleotide

• Length: 342 bp

>T31090 NZ_AP017367:2188458-2188799 [Leptolyngbya sp. O-77]
ATGACAACCATTTGGATCGATGCACATTTGTCTCCGGCGATAGCAACCTGGATCACAGATACCTTTGGGATTACAGCGTT
GGCGTTACGGGATCTTGGTCTACGAGATGCAGAAGACCCTGAAATCTTTGAGGCTGCAAAGGCTCAAGGAGTAATTTTTA
TGACGAAAGATAGTGATTTTGTAGATTTAGTTGAGCGATTGGGATCACCACCGCAAATTATCTGGTTGACTTGCGGCAAT
ACCTCAAATGCGAGGCTAAGGGAGATATTGAGTTCAGTTCTACCAGAAACACTAGAGTTGCTACGTTCTGGTGAAAAATT
AGTAGAGATCAGTGGGGATTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8248.65 Da
• Isoelectric Point: 5.7855

>AT31090 WP_084782999.1 NZ_AP017367:2188237-2188461 [Leptolyngbya sp. O-77]
MSKLLERITVNPRQCGGRPCIRGMRIRVSDVLDLFAAGLSAEEILEDLPDLEMDDLRASLTYAARKLNHPILVA

Nucleotide

• Length: 225 bp

>AT31090 NZ_AP017367:2188237-2188461 [Leptolyngbya sp. O-77]
ATGTCAAAGCTACTTGAACGAATTACAGTAAATCCCAGGCAATGTGGTGGTCGTCCCTGTATTCGTGGGATGAGAATTCG
AGTATCTGATGTTTTAGATTTGTTCGCAGCAGGTTTAAGTGCTGAAGAGATTTTAGAAGACTTGCCAGATTTAGAAATGG
ATGATCTACGAGCCTCCCTAACCTATGCAGCACGTAAATTGAACCATCCTATATTGGTGGCATGA