Detailed information of TA system TA031089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 362485..363131
• Replicon: chromosome
• Accession: NZ_AP017367
• Organism: Leptolyngbya sp. O-77

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: O77CONTIG1_RS01595
• Protein ID: WP_068507515.1
• Coordinates: 362727..363131 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: O77CONTIG1_RS23185
• Protein ID: WP_084781997.1
• Coordinates: 362485..362730 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O77CONTIG1_RS25315	358982..359599	+	618	WP_197673294.1	protein kinase	-
O77CONTIG1_RS24095	360238..360483	+	246	WP_156434818.1	hypothetical protein	-
O77CONTIG1_RS01580	360507..361205	-	699	WP_068515847.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
O77CONTIG1_RS01585	361219..362187	-	969	WP_068507512.1	isoaspartyl peptidase/L-asparaginase	-
O77CONTIG1_RS23180	362235..362414	-	180	WP_084781995.1	DUF2256 domain-containing protein	-
O77CONTIG1_RS23185	362485..362730	+	246	WP_084781997.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
O77CONTIG1_RS01595	362727..363131	+	405	WP_068507515.1	type II toxin-antitoxin system VapC family toxin	Toxin
O77CONTIG1_RS01600	363128..363739	-	612	WP_068507517.1	adenylate/guanylate cyclase domain-containing protein	-
O77CONTIG1_RS01605	363801..364460	-	660	WP_068507519.1	Uma2 family endonuclease	-
O77CONTIG1_RS01610	364757..365431	-	675	WP_068507520.1	ComF family protein	-
O77CONTIG1_RS01615	365790..366317	+	528	WP_197673295.1	translation initiation factor IF-3	-
O77CONTIG1_RS01620	366519..367004	-	486	WP_068507524.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
O77CONTIG1_RS23190	367292..367459	-	168	WP_084781999.1	metallothionein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (4-128)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-42)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15212.54 Da
• Isoelectric Point: 4.2280

>T31089 WP_068507515.1 NZ_AP017367:362727-363131 [Leptolyngbya sp. O-77]
VRLLLDTQCWLWWFAQPEKLSETVIEQIANEDNELWFSVASVWEMGIKASIGKLPLPEPIGDYVSTRMTQLGARSLEITA
AHAVQASMLPLHHRDPFDRMLIAQAQLEDLLLVSADSMFQQYEVTLLWAAVAMD

Nucleotide

• Length: 405 bp

>T31089 NZ_AP017367:362727-363131 [Leptolyngbya sp. O-77]
GTGAGGCTTTTACTAGATACTCAATGCTGGTTATGGTGGTTTGCTCAACCCGAAAAACTAAGTGAAACCGTGATTGAACA
AATCGCGAATGAGGACAATGAATTATGGTTCTCAGTCGCCAGTGTTTGGGAAATGGGCATTAAGGCTTCCATCGGCAAGC
TGCCGCTACCAGAGCCTATTGGTGATTATGTCTCGACCCGCATGACTCAGCTTGGGGCGCGGTCATTAGAAATTACAGCC
GCCCATGCGGTGCAGGCATCCATGCTGCCGCTTCATCATCGTGATCCGTTTGACCGAATGCTAATTGCCCAAGCCCAGTT
AGAAGACCTGCTGCTGGTTAGTGCAGACTCGATGTTTCAACAATATGAAGTTACTTTACTCTGGGCAGCCGTGGCAATGG
ACTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8810.00 Da
• Isoelectric Point: 5.0351

>AT31089 WP_084781997.1 NZ_AP017367:362485-362730 [Leptolyngbya sp. O-77]
METVNIHQAKTNLSRLLARVEQGEEIVIANRGVPVAKLVPFQTSLNRRSSLGRDRGVLTVPDDFNAPLPEDILAAFEGGA
E

Nucleotide

• Length: 246 bp

>AT31089 NZ_AP017367:362485-362730 [Leptolyngbya sp. O-77]
ATGGAAACTGTTAATATTCATCAGGCTAAGACAAATCTTTCTCGGTTACTGGCTCGGGTAGAGCAGGGGGAAGAAATTGT
GATCGCGAACCGGGGCGTTCCCGTGGCAAAGCTGGTTCCCTTTCAAACATCTTTGAATCGACGGTCTAGTTTAGGGCGAG
ATCGGGGGGTATTGACGGTGCCAGATGACTTTAATGCACCTTTACCAGAGGATATCTTAGCCGCTTTCGAGGGTGGGGCA
GAGTGA