Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 853319..853796 Replicon chromosome
Accession NZ_AP017320
Organism Staphylococcus aureus strain MI

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAMI_RS04095 Protein ID WP_000052076.1
Coordinates 853319..853507 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAMI_RS04100 Protein ID WP_001059690.1
Coordinates 853536..853796 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMI_RS04065 849313..849834 + 522 WP_000824482.1 hypothetical protein -
SAMI_RS04070 850175..850861 + 687 WP_000141557.1 thermonuclease family protein -
SAMI_RS04075 851218..851418 + 201 WP_001059082.1 cold-shock protein -
SAMI_RS04080 851910..852128 - 219 WP_000005886.1 hypothetical protein -
SAMI_RS04085 852190..852474 - 285 WP_001004399.1 hypothetical protein -
SAMI_RS04090 852562..853131 - 570 WP_001106658.1 hypothetical protein -
SAMI_RS04095 853319..853507 - 189 WP_000052076.1 hypothetical protein Toxin
SAMI_RS04100 853536..853796 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAMI_RS04105 854137..854340 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAMI_RS04110 854337..854573 - 237 WP_000349581.1 hypothetical protein -
SAMI_RS04115 854798..855379 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAMI_RS04120 855452..856069 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAMI_RS04125 856224..856718 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAMI_RS04130 857117..857539 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAMI_RS04135 857687..858403 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T31071 WP_000052076.1 NZ_AP017320:c853507-853319 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T31071 NZ_AP017320:c853507-853319 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT31071 WP_001059690.1 NZ_AP017320:c853796-853536 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT31071 NZ_AP017320:c853796-853536 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References