Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF-ParD
Location 4078822..4079460 Replicon chromosome
Accession NZ_AP017312
Organism Aneurinibacillus soli strain CB4

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag CB4_RS20530 Protein ID WP_096467534.1
Coordinates 4078822..4079172 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CB4_RS20535 Protein ID WP_096467535.1
Coordinates 4079176..4079460 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CB4_RS20500 4073933..4074412 - 480 WP_096467827.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
CB4_RS20505 4074445..4075461 - 1017 WP_096467529.1 thiamine-phosphate kinase -
CB4_RS20510 4075458..4075931 - 474 WP_096467530.1 SprT family protein -
CB4_RS20515 4076025..4076369 + 345 WP_096467531.1 hydrolase/acyltransferase -
CB4_RS20520 4076443..4076562 + 120 WP_096467532.1 cortex morphogenetic protein CmpA -
CB4_RS20525 4076586..4078739 - 2154 WP_096467533.1 RNA-binding transcriptional accessory protein -
CB4_RS20530 4078822..4079172 - 351 WP_096467534.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CB4_RS20535 4079176..4079460 - 285 WP_096467535.1 ribbon-helix-helix protein, CopG family Antitoxin
CB4_RS20540 4079722..4080909 - 1188 WP_096467536.1 alanine racemase -
CB4_RS20545 4081065..4081610 + 546 WP_096467537.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12917.86 Da        Isoelectric Point: 4.8435

>T31067 WP_096467534.1 NZ_AP017312:c4079172-4078822 [Aneurinibacillus soli]
VIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKSYAFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMDRVNDALQISLGLIDF

Download         Length: 351 bp

>T31067 NZ_AP017312:c4079172-4078822 [Aneurinibacillus soli]
GTGATTGTGAAGCGTGGCGATGTATATTTTGCGGACTTATCCCCTGTCGTGGGCTCGGAACAGGGCGGTGTAAGACCGGT
TTTAGTGATTCAAAATGATATTGGAAACCGTTTTAGTCCGACAGTTATCGTCGCAGCCATTACCGCACAGATACAGAAAG
CCAAATTACCTACTCATGTGGAGATCGATGCGAAGTCGTATGCATTTGATCGCGATTCCGTCATCCTTCTAGAACAAATC
CGCACGATCGATAAGCAGCGGCTAACAGACAAAATCACACATCTTGATGAAGAGATGATGGATCGGGTAAATGACGCTCT
CCAGATTAGTTTAGGACTTATTGATTTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11026.84 Da        Isoelectric Point: 7.3198

>AT31067 WP_096467535.1 NZ_AP017312:c4079460-4079176 [Aneurinibacillus soli]
MVLSKMDTKRIMISLPDHLLQEVDGLVEKEKSNRSEFIRQAMRLYLKERKKRHIREMMQRGYMEMANINLHMASEAFEAE
EEADSTLGRLVSGV

Download         Length: 285 bp

>AT31067 NZ_AP017312:c4079460-4079176 [Aneurinibacillus soli]
ATGGTCTTGTCGAAAATGGACACAAAGCGTATCATGATTAGCTTACCTGATCATCTTTTACAGGAAGTAGATGGTTTAGT
GGAAAAAGAAAAATCGAATCGTAGCGAGTTTATCCGTCAAGCGATGAGACTGTATTTGAAAGAGCGTAAGAAGCGCCATA
TTCGCGAGATGATGCAGCGCGGATACATGGAGATGGCGAATATCAATCTGCATATGGCAAGTGAGGCTTTTGAGGCCGAA
GAAGAAGCAGATTCAACCTTGGGACGTTTAGTGAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References