Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3910713..3911134 Replicon chromosome
Accession NZ_AP017308
Organism Leptolyngbya sp. NIES-3755

Toxin (Protein)


Gene name hicA Uniprot ID A0A0S3U761
Locus tag LEP3755_RS18905 Protein ID WP_068386311.1
Coordinates 3910922..3911134 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0S3U764
Locus tag LEP3755_RS18900 Protein ID WP_068386308.1
Coordinates 3910713..3910922 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEP3755_RS18875 3905895..3906446 + 552 WP_068386291.1 F0F1 ATP synthase subunit B -
LEP3755_RS18880 3906451..3907008 + 558 WP_068386294.1 F0F1 ATP synthase subunit delta -
LEP3755_RS18885 3907053..3908570 + 1518 WP_068386297.1 F0F1 ATP synthase subunit alpha -
LEP3755_RS18890 3908663..3909613 + 951 WP_068386300.1 F0F1 ATP synthase subunit gamma -
LEP3755_RS18895 3909713..3910600 - 888 WP_068386303.1 50S ribosome-binding GTPase -
LEP3755_RS18900 3910713..3910922 - 210 WP_068386308.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LEP3755_RS18905 3910922..3911134 - 213 WP_068386311.1 type II toxin-antitoxin system HicA family toxin Toxin
LEP3755_RS18910 3911256..3911501 + 246 WP_068386313.1 hypothetical protein -
LEP3755_RS18915 3911578..3912723 + 1146 WP_068380590.1 IS4 family transposase -
LEP3755_RS18920 3912774..3913034 + 261 WP_068386316.1 type II toxin-antitoxin system RelE/ParE family toxin -
LEP3755_RS18925 3912985..3913203 - 219 WP_068386321.1 type II toxin-antitoxin system HicB family antitoxin -
LEP3755_RS18930 3913192..3913695 + 504 WP_068386324.1 hypothetical protein -
LEP3755_RS18935 3913875..3914303 - 429 WP_059001024.1 FHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-66)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7924.03 Da        Isoelectric Point: 9.8135

>T31064 WP_068386311.1 NZ_AP017308:c3911134-3910922 [Leptolyngbya sp. NIES-3755]
MKVRAVIKRLEADGWYLARTKGSHRQFKHSEKSGTVTVSGKLSVDVPIGTLKSIWRQAQIEPIESEEEET

Download         Length: 213 bp

>T31064 NZ_AP017308:c3911134-3910922 [Leptolyngbya sp. NIES-3755]
ATGAAAGTCAGAGCCGTCATCAAGCGATTAGAAGCAGACGGTTGGTATCTTGCTCGAACGAAGGGAAGTCATCGACAGTT
CAAACATTCAGAGAAGTCGGGAACCGTTACAGTATCGGGAAAGCTCAGTGTTGATGTCCCGATTGGTACACTAAAAAGTA
TCTGGCGACAGGCGCAGATCGAGCCGATTGAATCTGAAGAGGAAGAAACCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7553.64 Da        Isoelectric Point: 3.9098

>AT31064 WP_068386308.1 NZ_AP017308:c3910922-3910713 [Leptolyngbya sp. NIES-3755]
MRYAIVIEKGQTSYGAYVPDLPGCVAVAETIEEVKELIQEAIVFHLEGLREDGLSIPEPISICEYVEAG

Download         Length: 210 bp

>AT31064 NZ_AP017308:c3910922-3910713 [Leptolyngbya sp. NIES-3755]
ATGCGATATGCGATTGTGATCGAAAAAGGACAAACCAGCTACGGTGCTTACGTTCCTGATCTTCCGGGTTGCGTGGCAGT
TGCGGAAACGATCGAGGAAGTCAAAGAATTGATTCAAGAAGCGATCGTGTTTCATCTAGAAGGACTGAGAGAAGATGGAT
TATCGATTCCTGAACCAATCTCGATTTGTGAATATGTTGAGGCTGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3U761

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3U764

References