Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 3760272..3760785 Replicon chromosome
Accession NZ_AP017308
Organism Leptolyngbya sp. NIES-3755

Toxin (Protein)


Gene name relB Uniprot ID A0A0S3U6Q2
Locus tag LEP3755_RS18130 Protein ID WP_068385982.1
Coordinates 3760519..3760785 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0S3U6J7
Locus tag LEP3755_RS18125 Protein ID WP_068385980.1
Coordinates 3760272..3760526 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEP3755_RS18085 3755295..3755483 + 189 WP_068385968.1 hypothetical protein -
LEP3755_RS18090 3755539..3756099 - 561 WP_068385970.1 rod shape-determining protein MreD -
LEP3755_RS18095 3756096..3756956 - 861 WP_068385972.1 rod shape-determining protein MreC -
LEP3755_RS18100 3757055..3758056 - 1002 WP_059000572.1 rod shape-determining protein -
LEP3755_RS18105 3758319..3758681 + 363 WP_068385974.1 single-stranded DNA-binding protein -
LEP3755_RS18110 3758745..3759284 - 540 WP_084762042.1 Spy/CpxP family protein refolding chaperone -
LEP3755_RS18115 3759226..3759549 - 324 WP_068385977.1 hypothetical protein -
LEP3755_RS18120 3759546..3760115 - 570 WP_068393304.1 sigma-70 family RNA polymerase sigma factor -
LEP3755_RS18125 3760272..3760526 + 255 WP_068385980.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LEP3755_RS18130 3760519..3760785 + 267 WP_068385982.1 Txe/YoeB family addiction module toxin Toxin
LEP3755_RS18135 3760860..3761762 + 903 WP_068385987.1 SDR family oxidoreductase -
LEP3755_RS18140 3761762..3762943 + 1182 WP_068385988.1 succinate--CoA ligase subunit beta -
LEP3755_RS18145 3763313..3764221 + 909 WP_068385989.1 CoA-binding protein -
LEP3755_RS18150 3764223..3764708 - 486 WP_068385990.1 DUF4383 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10415.75 Da        Isoelectric Point: 6.9759

>T31063 WP_068385982.1 NZ_AP017308:3760519-3760785 [Leptolyngbya sp. NIES-3755]
MSRKLAWTEEAWNDYVYWQGQDKKTLKRINKLIQETLRSPLEGIGKPEALSGNLTGFWSRRIDETNRLVYAVDDDYLTII
ACRYHYSD

Download         Length: 267 bp

>T31063 NZ_AP017308:3760519-3760785 [Leptolyngbya sp. NIES-3755]
ATGAGTAGAAAGCTCGCTTGGACTGAAGAAGCCTGGAACGACTATGTCTATTGGCAAGGTCAAGATAAGAAGACGTTAAA
GCGGATTAACAAACTGATTCAAGAGACTCTACGATCGCCCCTGGAGGGAATCGGAAAGCCAGAAGCACTCAGCGGCAATT
TGACTGGGTTCTGGTCGCGTCGTATCGATGAAACGAATCGGCTAGTTTACGCAGTTGACGATGACTATCTCACGATTATT
GCTTGTCGATACCACTACTCCGATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9598.89 Da        Isoelectric Point: 4.4978

>AT31063 WP_068385980.1 NZ_AP017308:3760272-3760526 [Leptolyngbya sp. NIES-3755]
MDIVSFSEARNNLKAVLDRVVEDADFTVITRRDAEDVVVMSLELFNRLMETDYLLKSPANAAHLERSIAQYKQGKAIERN
LVDE

Download         Length: 255 bp

>AT31063 NZ_AP017308:3760272-3760526 [Leptolyngbya sp. NIES-3755]
ATGGATATTGTTTCTTTTAGCGAAGCAAGAAATAACCTGAAGGCTGTTTTAGATCGTGTGGTCGAAGATGCTGACTTTAC
AGTGATTACGCGACGGGACGCAGAGGATGTGGTTGTGATGTCGCTGGAGTTGTTTAATCGTTTGATGGAGACGGATTATC
TGCTTAAATCTCCAGCAAATGCGGCTCATTTAGAGCGATCGATTGCTCAATACAAGCAAGGAAAGGCGATCGAACGGAAC
CTAGTGGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3U6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3U6J7

References