Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT2-ataR/GNAT-DUF1778
Location 1440587..1441356 Replicon chromosome
Accession NZ_AP017308
Organism Leptolyngbya sp. NIES-3755

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0S3U062
Locus tag LEP3755_RS06635 Protein ID WP_068382046.1
Coordinates 1440847..1441356 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A0S3U053
Locus tag LEP3755_RS06630 Protein ID WP_068382044.1
Coordinates 1440587..1440856 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEP3755_RS06605 1436085..1436396 - 312 WP_068382036.1 co-chaperone GroES -
LEP3755_RS33875 1437674..1437745 + 72 Protein_1304 hypothetical protein -
LEP3755_RS06615 1437766..1438290 + 525 WP_068392795.1 N-acetyltransferase -
LEP3755_RS06620 1438508..1439059 - 552 WP_068382040.1 adenylate kinase -
LEP3755_RS06625 1439059..1440363 - 1305 WP_068382042.1 preprotein translocase subunit SecY -
LEP3755_RS06630 1440587..1440856 + 270 WP_068382044.1 DUF1778 domain-containing protein Antitoxin
LEP3755_RS06635 1440847..1441356 + 510 WP_068382046.1 GNAT family N-acetyltransferase Toxin
LEP3755_RS06640 1441888..1442760 + 873 WP_068382048.1 Rpn family recombination-promoting nuclease/putative transposase -
LEP3755_RS06645 1442879..1443370 - 492 WP_068382050.1 DUF3368 domain-containing protein -
LEP3755_RS06650 1443367..1443612 - 246 WP_068382052.1 UPF0175 family protein -
LEP3755_RS06655 1443649..1444269 - 621 WP_068382054.1 UbiX family flavin prenyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-146)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18844.54 Da        Isoelectric Point: 6.9322

>T31061 WP_068382046.1 NZ_AP017308:1440847-1441356 [Leptolyngbya sp. NIES-3755]
VGIEQLRPPERIRSSYQFEDFDSGNSQLNDWLTRRALKNEAEGASRTYVLCEGETVVAYYCLSNGSIAQSEATGRIRRNM
PDPIPVMVIGRLAVDRQWQGKGIGRALLRDAILRTLQAAEIAGIRAILVHAISEEAKQFYQKCGFTVSPSNEMTLMIRVQ
DAIASLEPM

Download         Length: 510 bp

>T31061 NZ_AP017308:1440847-1441356 [Leptolyngbya sp. NIES-3755]
GTGGGAATAGAGCAGCTTCGTCCACCTGAGAGAATCCGTTCATCTTATCAGTTTGAGGACTTCGATTCTGGGAACAGTCA
ACTAAACGACTGGCTAACGCGCCGCGCCTTGAAGAATGAGGCAGAAGGAGCCTCTCGAACCTACGTGTTATGTGAGGGCG
AAACGGTTGTTGCGTATTACTGTCTTTCCAATGGCAGCATTGCACAATCTGAGGCGACAGGTCGAATTCGTCGGAATATG
CCTGATCCGATTCCGGTTATGGTGATTGGACGATTAGCCGTCGATCGACAATGGCAAGGAAAAGGAATCGGACGTGCTCT
GCTTCGAGATGCAATTTTAAGAACGCTACAAGCCGCGGAAATTGCAGGCATTCGAGCAATTCTGGTTCATGCGATTTCAG
AAGAAGCCAAACAGTTTTATCAGAAATGCGGGTTTACAGTTTCACCGAGCAATGAGATGACTTTGATGATTCGGGTGCAA
GATGCGATCGCGTCGCTTGAGCCGATGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10331.62 Da        Isoelectric Point: 4.5741

>AT31061 WP_068382044.1 NZ_AP017308:1440587-1440856 [Leptolyngbya sp. NIES-3755]
MDQTRDVTINIRATQSQRDLIDCAAEVQGKSRSEFMLESAYQRAQDVLLDRCFFALDQQKFEQFEALLNQPPAPNDKLRN
LLNTKAPWE

Download         Length: 270 bp

>AT31061 NZ_AP017308:1440587-1440856 [Leptolyngbya sp. NIES-3755]
ATGGATCAAACTCGTGATGTCACGATTAATATTCGCGCTACACAGAGTCAGAGAGATTTGATTGATTGTGCGGCTGAAGT
TCAGGGCAAGAGTCGATCGGAATTTATGCTGGAGTCGGCATATCAGAGAGCGCAAGACGTTTTACTCGATCGCTGTTTTT
TCGCATTAGATCAACAGAAATTTGAGCAATTTGAAGCGCTTCTGAATCAGCCACCTGCACCAAACGACAAGCTGCGTAAT
CTCCTAAACACAAAAGCGCCGTGGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3U062

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3U053

References