Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /PIN(toxin)
Location 762352..762981 Replicon chromosome
Accession NZ_AP017308
Organism Leptolyngbya sp. NIES-3755

Toxin (Protein)


Gene name - Uniprot ID A0A0S3TYE5
Locus tag LEP3755_RS03525 Protein ID WP_068380518.1
Coordinates 762352..762759 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0S3TYB1
Locus tag LEP3755_RS03530 Protein ID WP_068380520.1
Coordinates 762760..762981 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEP3755_RS03510 758839..760194 + 1356 WP_068380511.1 restriction endonuclease subunit S -
LEP3755_RS03515 760203..761480 + 1278 WP_068380512.1 AAA family ATPase -
LEP3755_RS03520 761455..762156 + 702 WP_068380516.1 TIGR02646 family protein -
LEP3755_RS03525 762352..762759 - 408 WP_068380518.1 PIN domain-containing protein Toxin
LEP3755_RS03530 762760..762981 - 222 WP_068380520.1 hypothetical protein Antitoxin
LEP3755_RS03535 763089..766100 + 3012 WP_068380522.1 type I restriction endonuclease subunit R -
LEP3755_RS03540 766090..766755 - 666 WP_068392639.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14869.08 Da        Isoelectric Point: 4.1085

>T31060 WP_068380518.1 NZ_AP017308:c762759-762352 [Leptolyngbya sp. NIES-3755]
MRVLIDTNVVLDFLQEREPFVEDAARLFERIDAGEIEGFIAATTITNIYYIVRKAAGVEASEEAISQILSDLQICAVDRA
ILEQAVILKFRDFEDAVQYACAIAYGVDAIVTRDLSGFTSAAIPVKSPRELIGLL

Download         Length: 408 bp

>T31060 NZ_AP017308:c762759-762352 [Leptolyngbya sp. NIES-3755]
ATGCGAGTTTTGATTGATACGAATGTAGTTCTAGATTTTTTACAGGAAAGAGAGCCATTTGTAGAGGATGCTGCTCGATT
GTTTGAGCGAATTGATGCAGGAGAGATTGAAGGTTTTATTGCTGCAACTACGATTACTAATATCTATTACATTGTTCGGA
AAGCAGCAGGGGTAGAGGCATCTGAAGAGGCTATCAGTCAAATTCTCAGTGATTTGCAGATTTGTGCAGTCGATCGAGCA
ATTTTAGAACAAGCCGTTATTTTGAAATTTCGAGATTTTGAGGATGCGGTTCAGTATGCTTGTGCGATCGCTTATGGTGT
TGATGCGATCGTGACTCGCGATTTGTCCGGGTTTACGAGTGCAGCAATTCCAGTTAAGTCGCCAAGAGAATTGATCGGAT
TATTATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8485.74 Da        Isoelectric Point: 6.3002

>AT31060 WP_068380520.1 NZ_AP017308:c762981-762760 [Leptolyngbya sp. NIES-3755]
MTLQELQKQVLQLPIRERWQLVQTVLLSLQEETSLEKKPKNLSRLRGIAKVAPTPTDAENAEDYATYLTEKYQ

Download         Length: 222 bp

>AT31060 NZ_AP017308:c762981-762760 [Leptolyngbya sp. NIES-3755]
ATGACACTACAAGAATTGCAAAAACAGGTCTTGCAATTGCCGATTCGAGAGCGATGGCAATTAGTTCAGACGGTTCTTCT
TTCTTTGCAGGAAGAGACATCTTTAGAGAAGAAGCCGAAAAATCTATCTCGTCTCCGGGGAATTGCGAAGGTTGCACCCA
CGCCAACGGACGCTGAGAATGCTGAAGATTACGCAACTTATCTGACTGAGAAATACCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3TYE5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3TYB1

References