Detailed information of TA system TA031058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 3860163..3860562
• Replicon: chromosome
• Accession: NZ_AP017305
• Organism: Fischerella sp. NIES-3754

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FIS3754_RS25640
• Protein ID: WP_178379588.1
• Coordinates: 3860163..3860330 (-)
• Length: 56 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0S3TQP9
• Locus tag: FIS3754_RS15800
• Protein ID: WP_062247975.1
• Coordinates: 3860320..3860562 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIS3754_RS15790	3856437..3857417	+	981	WP_062247972.1	sucrase ferredoxin	-
FIS3754_RS15795	3858298..3859578	-	1281	WP_062247973.1	histidinol dehydrogenase	-
FIS3754_RS25635	3859739..3859924	-	186	WP_102207098.1	hypothetical protein	-
FIS3754_RS25640	3860163..3860330	-	168	WP_178379588.1	hypothetical protein	Toxin
FIS3754_RS15800	3860320..3860562	-	243	WP_062247975.1	hypothetical protein	Antitoxin
FIS3754_RS15805	3860692..3861120	-	429	WP_062247976.1	hypothetical protein	-
FIS3754_RS15810	3861226..3861702	+	477	WP_062247977.1	MEKHLA domain-containing protein	-
FIS3754_RS15815	3861846..3864017	-	2172	WP_062247978.1	tyrosine-protein kinase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-71)

Sequences

Toxin

Protein

• Length: 56 a.a.
• Molecular weight: 6396.39 Da
• Isoelectric Point: 8.0214

>T31058 WP_178379588.1 NZ_AP017305:c3860330-3860163 [Fischerella sp. NIES-3754]
MQSEPSLVQVNFTDEFQRCLRTLSKKYRHIRSDIQPIIAQLQAGDFVGFFVLNIP

Nucleotide

• Length: 168 bp

>T31058 NZ_AP017305:c3860330-3860163 [Fischerella sp. NIES-3754]
ATGCAGAGTGAACCATCCTTAGTTCAAGTTAATTTTACAGATGAATTTCAGCGTTGTCTACGTACCCTATCCAAAAAGTA
TCGTCACATTCGGTCTGATATTCAGCCGATAATTGCACAACTGCAAGCAGGAGATTTTGTTGGTTTTTTTGTATTAAATA
TACCGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.97 Da
• Isoelectric Point: 4.0746

>AT31058 WP_062247975.1 NZ_AP017305:c3860562-3860320 [Fischerella sp. NIES-3754]
MRAQEVMGNVDENGTLCLDEPLTVQKHSRVKVIVLFVEDDMDEDDESKESVLNSLRTSLQEAKAGKTRPVSELWDGIDAE

Nucleotide

• Length: 243 bp

>AT31058 NZ_AP017305:c3860562-3860320 [Fischerella sp. NIES-3754]
ATGAGGGCGCAAGAAGTAATGGGAAACGTTGACGAAAACGGTACACTCTGCTTAGATGAACCGCTAACGGTACAAAAGCA
TAGTCGCGTTAAGGTGATTGTGCTGTTTGTGGAAGATGATATGGATGAAGATGATGAATCAAAAGAGTCTGTATTAAACA
GTCTTCGCACTTCATTGCAAGAAGCAAAAGCTGGAAAAACCAGACCTGTTTCAGAACTCTGGGATGGAATTGATGCAGAG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0S3TQP9